Kaji K, Unoura M, Kobayashi K, Nakanuma Y
1st Department of Internal Medicine, Kanazawa University School of Medicine.
Nihon Rinsho. 1994 Jul;52(7):1865-8.
Autoimmune hepatitis (AIH) with hepatitis C virus (HCV) markers are seen frequently after the establishment of the method to detect HCV markers. According to the mechanism of the liver injury, we divide these cases of AIH with HCV markers to three groups; 1) the cases of AIH with HCV infection incidentally, 2) the cases of AIH triggered by HCV infection, and 3) the cases of chronic hepatitis C with immunological abnormalities. As far as we don't have any markers to differentiate these cases, we now think we should treat such cases with steroids at first before administering interferon, when we are not sure about the mechanism of the liver injury, because interferon is thought to be more risky than steroid for the cases who may have immunological abnormalities.
在检测丙型肝炎病毒（HCV）标志物的方法确立后，常可见到伴有HCV标志物的自身免疫性肝炎（AIH）。根据肝损伤机制，我们将这些伴有HCV标志物的AIH病例分为三组：1）偶发HCV感染的AIH病例；2）由HCV感染引发的AIH病例；3）伴有免疫异常的慢性丙型肝炎病例。由于我们尚无区分这些病例的标志物，目前认为，当我们不确定肝损伤机制时，对于可能存在免疫异常的病例，在给予干扰素之前应先用类固醇治疗，因为对于这类病例，干扰素被认为比类固醇风险更高。
