Salgia R, Demetri G D, Kaplan W D
Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115.
Cancer. 1994 Oct 1;74(7):1887-90. doi: 10.1002/1097-0142(19941001)74:7<1887::aid-cncr2820740710>3.0.co;2-6.
Granulocyte colony stimulating factor (G-CSF) is used clinically for chemotherapy-associated neutropenia. Very little is known about the manner in which pharmacologic dosing of G-CSF may affect radiologic studies in vivo. Dramatic changes on bone scan associated with the administration of G-CSF used to support dose-intensified combination chemotherapy in a patient with metastatic breast carcinoma are described. The scintigraphic findings were correlated histologically with increased hematopoietic activity in the bone marrow located in peripheral bones.
粒细胞集落刺激因子（G-CSF）在临床上用于治疗化疗相关的中性粒细胞减少症。关于G-CSF的药理剂量在体内影响放射学研究的方式，人们知之甚少。本文描述了一名转移性乳腺癌患者在接受支持剂量强化联合化疗时使用G-CSF后骨扫描出现的显著变化。骨闪烁显像结果与外周骨骨髓造血活性增加的组织学表现相关。
