Herr W, Schwarting A, Wittig B, Wanitschke R, Schnitzler G, Weinerth J, Jochum W, Hake U, Meyer zum Büschenfelde K H
I. Medizinische Klinik, Johannes-Gutenberg-Universität Mainz, Germany.
Clin Investig. 1994 May;72(5):372-6. doi: 10.1007/BF00252830.
This report describes a 26-year-old patient with hemangiosarcoma of the heart and summarizes the clinicopathological features in previous reports of patients with cardiac angiosarcoma. The patient was admitted to our hospital because of a syncope and one episode of nocturnal dyspnea and hemoptysis. In his history he complained of progressive weakness and loss of weight over the past 2 months. Echocardiography and computed tomography of the chest showed inhomogeneous masses in the pericardial cavity completely surrounding the heart and involving the ascending aorta and the superior vena cava. Histological examination of the tissue obtained from the mass by fine needle technique revealed a poorly differentiated malignant tumor of mesenchymal origin. Exploratory thoracotomy followed by tumor biopsies showed an inoperable cardiac hemangiosarcoma of enormous size with multiple metastases in both lungs. Palliative tumor resection was not performed. During the postoperative course the patient still required controlled ventilation. After 3 days of cytostatic chemotherapy no regression of tumor mass was seen by chest radiography. Cardiorespiratory insufficiency was progressive, and the patient died within 3 weeks after admission.
本报告描述了一名患有心脏血管肉瘤的26岁患者，并总结了既往心脏血管肉瘤患者报告中的临床病理特征。该患者因晕厥、一次夜间呼吸困难和咯血入院。据其病史，他在过去2个月中出现进行性虚弱和体重减轻。超声心动图和胸部计算机断层扫描显示心包腔内有不均匀肿块，完全包绕心脏，并累及升主动脉和上腔静脉。通过细针技术从肿块获取的组织进行组织学检查，显示为间叶源性低分化恶性肿瘤。开胸探查并进行肿瘤活检显示为无法手术切除的巨大心脏血管肉瘤，双肺有多处转移。未进行姑息性肿瘤切除。术后病程中，患者仍需控制通气。细胞毒性化疗3天后，胸部X线检查未见肿瘤肿块缩小。心肺功能不全呈进行性发展，患者在入院后3周内死亡。
