Chany C, Kaba A, Jiang P H, Chany-Fournier F
Université Pierre-et-Marie-Curie, Laboratoire de Physiologie Cellulaire, Paris, France.
C R Acad Sci III. 1993 Nov;316(11):1286-9.
Prolonged interferon (IFN) treatment can convert Moloney sarcoma-transformed mouse Balb C fibroblasts to a stable non-malignant status. The cells recover a number of differentiated features, which are maintained even when IFN is permanently omitted from the tissue culture medium. We show here that reversion could be at least in part attributed to constitutive IFN beta synthesized only in the reverted cells. The continued replication of these cells, although unable to induce tumours in athymic mice, could be the result of the maintained expression of an IFN antagonist termed sarcolectin (SCL), a balance being struck between the effects of v-mos oncogene, interferon beta and SCLs. In agreement with Lampl et al. [11], we suggest that normal cell growth is discontinuous, consisting of sudden bursts followed by prolonged arrests which could be necessary to promote differentiation during the ensuing interphase.
长期干扰素（IFN）治疗可使莫洛尼肉瘤转化的小鼠Balb C成纤维细胞转变为稳定的非恶性状态。这些细胞恢复了许多分化特征，即使在组织培养基中永久去除干扰素后，这些特征仍能保持。我们在此表明，细胞逆转至少部分归因于仅在逆转细胞中合成的组成型IFN-β。这些细胞的持续复制虽然不能在无胸腺小鼠中诱导肿瘤，但可能是由于一种名为肌集蛋白（SCL）的IFN拮抗剂持续表达的结果，在v-mos癌基因、干扰素β和SCL的作用之间达成了平衡。与兰普尔等人[11]的观点一致，我们认为正常细胞生长是不连续的，由突然的增殖爆发和随后的长期停滞组成，这对于在随后的间期促进分化可能是必要的。
