Gay N J, Hesketh L M, Cohen B J, Rush M, Bates C, Morgan-Capner P, Miller E
Preston Public Health Laboratory.
Commun Dis Rep CDR Rev. 1994 Aug 19;4(9):R104-7.
Infection with parvovirus B19 is an important cause of late fetal mortality in the second trimester, and many infections in pregnancy remain undiagnosed. A serological survey stratified by age has been used to estimate the incidence of maternal infection with parvovirus B19 in pregnancy. Serum remaining from specimens submitted for diagnosis from 6864 people of all ages to seven public health laboratories in England was tested for antibody to parvovirus B19. The antibody prevalence rose with age to 45% at 10 years and 60% to 70% in adults. The age specific force of infection was highest in children aged less than 10 years and lowest in adults. Maternal infection with parvovirus B19 is estimated to occur in approximately one pregnancy in 400. It has been estimated that fetal death occurs in 9% of these cases, which suggests that parvovirus B19 may cause more than 150 fetal deaths in England and Wales each year. Testing for evidence of recent infection with parvovirus B19 should be considered for unexplained cases of fetal hydrops in the second trimester, especially in years of parvovirus B19 epidemics.
B19细小病毒感染是孕中期胎儿晚期死亡的一个重要原因，许多孕期感染仍未得到诊断。一项按年龄分层的血清学调查已被用于估计孕期孕妇感染B19细小病毒的发生率。对提交至英格兰七个公共卫生实验室进行诊断的来自各年龄段6864人的标本剩余血清进行了B19细小病毒抗体检测。抗体流行率随年龄增长而上升，10岁时达到45%，成年人中为60%至70%。年龄特异性感染率在10岁以下儿童中最高，在成年人中最低。估计每400次怀孕中约有1次发生孕妇感染B19细小病毒。据估计，这些病例中有9%会发生胎儿死亡，这表明B19细小病毒每年可能在英格兰和威尔士导致150多例胎儿死亡。对于孕中期不明原因的胎儿水肿病例，尤其是在B19细小病毒流行年份，应考虑检测近期感染B19细小病毒的证据。
