Menestrina F, Lestani M, Scarpa A, Viale G, Bonetti F, Pizzolo G, Chilosi M
Istituto di Anatomia Patologica, Università di Verona, Italy.
Virchows Arch. 1994;425(1):83-7. doi: 10.1007/BF00193954.
This report presents a case of common acute lymphoblastic leukaemia-lymphoma expressing low molecular weight cytokeratin but no leukocyte common antigen (CD45) in a 57-year-old man. The unusual morphology and clinical course together with the aberrant immunohistochemical results suggested a diagnosis of undifferentiated carcinoma. A detailed immunohistochemistry study on frozen and paraffin sections and molecular analysis prevented a diagnostic mistake.
本报告介绍了一名57岁男性患普通急性淋巴细胞白血病-淋巴瘤的病例,该病例表达低分子量细胞角蛋白,但不表达白细胞共同抗原(CD45)。异常的形态学、临床病程以及异常的免疫组化结果提示诊断为未分化癌。对冰冻切片和石蜡切片进行的详细免疫组化研究及分子分析避免了诊断错误。