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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Jing J, Aitken P G, Somjen G G

Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710.

J Neurophysiol. 1994 Jun;71(6):2548-51. doi: 10.1152/jn.1994.71.6.2548.

Relative interstitial volume (ISV) was estimated from the concentration changes of iontophoretically administered tetramethyl- and tetraethylammonium (TMA+ and TEA+). Spreading depression (SD) was provoked by high K+, and hypoxic SD-like depolarization (HSD) was induced by withdrawing oxygen. 2. Probe ion concentrations increased dramatically and about equally during SD and HSD, except that in a few hypoxic trials signals became transiently smaller than control. Interstitial volume appeared to decrease on the average by approximately 70%. 3. The ISV that remains patent in CA1 region at the height of SD is < 4% of total tissue volume. Probe ions may occasionally have passed through cell membranes for a short time during hypoxic SD.

相对细胞外间隙容积（ISV）通过离子电渗法施用四甲基铵和四乙基铵（TMA⁺和TEA⁺）的浓度变化来估算。高钾诱发扩散性抑制（SD），缺氧诱导缺氧性SD样去极化（HSD）。2. 在SD和HSD期间，探针离子浓度急剧且大致同等程度地增加，只是在少数缺氧试验中信号短暂小于对照。细胞外间隙容积平均似乎减少约70%。3. 在SD高峰时CA1区仍保持开放的ISV小于总组织容积的4%。在缺氧性SD期间，探针离子可能偶尔短时间穿过细胞膜。

Jing J, Aitken P G, Somjen G G

Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710.

J Neurophysiol. 1994 Jun;71(6):2548-51. doi: 10.1152/jn.1994.71.6.2548.

Relative interstitial volume (ISV) was estimated from the concentration changes of iontophoretically administered tetramethyl- and tetraethylammonium (TMA+ and TEA+). Spreading depression (SD) was provoked by high K+, and hypoxic SD-like depolarization (HSD) was induced by withdrawing oxygen. 2. Probe ion concentrations increased dramatically and about equally during SD and HSD, except that in a few hypoxic trials signals became transiently smaller than control. Interstitial volume appeared to decrease on the average by approximately 70%. 3. The ISV that remains patent in CA1 region at the height of SD is < 4% of total tissue volume. Probe ions may occasionally have passed through cell membranes for a short time during hypoxic SD.

相对细胞外间隙容积（ISV）通过离子电渗法施用四甲基铵和四乙基铵（TMA⁺和TEA⁺）的浓度变化来估算。高钾诱发扩散性抑制（SD），缺氧诱导缺氧性SD样去极化（HSD）。2. 在SD和HSD期间，探针离子浓度急剧且大致同等程度地增加，只是在少数缺氧试验中信号短暂小于对照。细胞外间隙容积平均似乎减少约70%。3. 在SD高峰时CA1区仍保持开放的ISV小于总组织容积的4%。在缺氧性SD期间，探针离子可能偶尔短时间穿过细胞膜。