Clozel M, Kuhn H, Baumgartner H R
Department of PRPV, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
J Cardiovasc Pharmacol. 1993;22 Suppl 4:S15-8. doi: 10.1097/00005344-199322004-00003.
Both the function and the morphology of the vascular intima are altered during hypertension. In spontaneously hypertensive rats, endothelium-dependent relaxation is decreased, and the subendothelium becomes infiltrated with monocyte macrophages. It is not known if these two features are secondary to high blood pressure and what their consequences are; however, both can be reversed by angiotensin-converting enzyme (ACE) inhibition. The present paper summarizes the effects of a chronic treatment with the ACE inhibitor cilazapril on endothelial function and subendothelial morphology in spontaneously hypertensive rats.
在高血压期间，血管内膜的功能和形态都会发生改变。在自发性高血压大鼠中，内皮依赖性舒张功能降低，内皮下层出现单核巨噬细胞浸润。目前尚不清楚这两个特征是否继发于高血压及其后果是什么；然而，两者都可以通过抑制血管紧张素转换酶（ACE）来逆转。本文总结了用ACE抑制剂西拉普利长期治疗对自发性高血压大鼠内皮功能和内皮下形态的影响。
