Nersessian A K
V.A. Fanardjian Centre for Oncology Research, CIS, Armenia.
Mutat Res. 1994 Oct;322(4):287-90. doi: 10.1016/0165-1218(94)90104-x.
Thiotepa (TT) induced chromosomal aberrations in the bone marrow cells of the Armenian hamster, Cricetulus migratorius, in a dose-dependent manner. The maximal clastogenic action was observed 24 h after treatment with thiotepa. Male and female Armenian hamsters were similarly sensitive to the clastogenic action of thiotepa. The lowest effective concentration of thiotepa for Armenian hamsters was 2.5 mg/kg b.w. (6.1% of the LD50). The results obtained and analysis of the literature data have shown that Armenian hamsters are much more resistant to the clastogenic action of thiotepa than various other species of rodent. This resistance is not due to the metabolic activation rates of chemical mutagen in the liver of Armenian hamsters, since thiotepa is a direct-acting clastogen.
噻替派（TT）可剂量依赖性地诱导亚美尼亚仓鼠（黑线仓鼠）骨髓细胞出现染色体畸变。在用噻替派处理24小时后观察到最大致断裂作用。雄性和雌性亚美尼亚仓鼠对噻替派的致断裂作用同样敏感。亚美尼亚仓鼠对噻替派的最低有效浓度为2.5毫克/千克体重（LD50的6.1%）。获得的结果以及对文献数据的分析表明，亚美尼亚仓鼠对噻替派的致断裂作用比其他各种啮齿动物更具抗性。这种抗性并非由于亚美尼亚仓鼠肝脏中化学诱变剂的代谢活化率，因为噻替派是一种直接作用的致断裂剂。
