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[甲状腺滤泡性病变针吸术的术前细胞诊断]

[Preoperative cytodiagnosis by needle aspiration of follicular thyroid lesions].

作者信息

Fadda G, Rabitti C, Verzì A, Gullotta G, Lancia M, Bianchi A, Capelli A

机构信息

Istituto di Anatomia e Istologia patologica, Università Cattolica del S. Cuore, Roma.

出版信息

Pathologica. 1994 Apr;86(2):196-201.

PMID:7524012
Abstract

In the period 1989-92, 2729 F.N.A.B. were performed: 585 with an histological control were reviewed. The aim of the study was to evaluate the risk of carcinomatous occurrence in the follicular-structured smears and to suggest a new cytodiagnostic classification. Out of 398 follicular-structured smears, 188 were colloid nodules (CN), 38 thyreocytic hyperplasias without nuclear atypia (THWNA), 146 predominantly follicular lesions (PFL), 26 follicular lesions with nuclear pleomorphism (FLWNP). The last one showed a high incidence of neoplasia (69.2%) and carcinoma (46.1%); the second and the third only a difference in the incidence of benign neoplasms (32.9 vs. 15.8%), with almost the same percentage of occurrence of malignancies (2.6 vs. 2.1%). Such results suggest that a six-months dilatory strategy might be useful in simple follicular lesions (THWNA and PFL) whereas a cytological follicular pattern with nuclear pleomorphism requires a surgical treatment for the high risk of carcinomatous occurrence.

摘要

在1989年至1992年期间,共进行了2729次细针穿刺抽吸活检(F.N.A.B.):对其中585例有组织学对照的病例进行了回顾性研究。本研究的目的是评估滤泡结构涂片发生癌变的风险,并提出一种新的细胞诊断分类方法。在398例滤泡结构涂片中,188例为胶质结节(CN),38例为无核异型性的甲状腺细胞增生(THWNA),146例为主要为滤泡性病变(PFL),26例为有核多形性的滤泡性病变(FLWNP)。最后一组显示肿瘤发生率高(69.2%)和癌变率高(46.1%);第二组和第三组仅在良性肿瘤发生率上有差异(32.9%对15.8%),恶性肿瘤发生率几乎相同(2.6%对2.1%)。这些结果表明,对于单纯滤泡性病变(THWNA和PFL),六个月的延期策略可能是有用的,而有核多形性的细胞学滤泡模式因癌变风险高而需要手术治疗。

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