Yao D F, Horie C, Horie T, Shimizu I, Meng X Y, Ito S
2nd Department of Internal Medicine, School of Medicine, University of Tokushima, Japan.
Tokushima J Exp Med. 1994 Jun;41(1-2):49-56.
The prevalence, genotypes, coinfection and putative core gene sequence of hepatitis C virus (HCV) were investigated in the inshore area of the Yangtze River, where hepatocellular carcinoma (HCC) is thought to be very common. Most patients with liver diseases were infected with hepatitis B virus (HBV), but the incidence of anti-HCV was very low, being 3.4% in patients with acute hepatitis, and approximately 7% in those with chronic liver diseases. The rate of coinfection with HBV and HCV in patients with HCC was 4.5%, which was similar to that in Shanghai (5.6%), but lower than that in Yangzhou (31.2%), Beijing (26.8%) and Zhejiang (28.6%). Of 124 patients with non-A, non-B (NANB) liver disease, 15 (12.1%) were positive for anti-HCV. HCV genotype analysis in 41 HCV-RNA-positive patients with liver diseases showed that genotype II was dominant (85.4%), followed by genotype III (7.3%) and II+III (7.3%). No genotype I or IV was found. The genome sequences of the HCV putative core gene from two patients with chronic hepatitis were more closely similar to those of previous isolates from Japan and China, than to that of an American isolate. These results suggest that HCV infection is not an important etiological factor for liver diseases, and that the HCV isolates in China are from the same subgroup as those in Japan.
在长江沿岸地区对丙型肝炎病毒（HCV）的流行情况、基因型、合并感染及假定核心基因序列进行了调查，该地区肝细胞癌（HCC）被认为非常常见。大多数肝病患者感染了乙型肝炎病毒（HBV），但抗-HCV的发生率很低，急性肝炎患者中为3.4%，慢性肝病患者中约为7%。HCC患者中HBV与HCV合并感染率为4.5%，与上海（5.6%）相似，但低于扬州（31.2%）、北京（26.8%）和浙江（28.6%）。在124例非甲非乙型（NANB）肝病患者中，15例（12.1%）抗-HCV呈阳性。对41例HCV-RNA阳性肝病患者的HCV基因型分析显示，II型为主（85.4%），其次是III型（7.3%）和II+III型（7.3%）。未发现I型或IV型。两名慢性肝炎患者HCV假定核心基因的基因组序列与日本和中国先前分离株的序列比与美国分离株的序列更相似。这些结果表明，HCV感染不是肝病的重要病因，且中国的HCV分离株与日本的分离株属于同一亚组。
