Yates B J, Grélot L, Kerman I A, Balaban C D, Jakus J, Miller A D
Laboratory of Neurophysiology, Rockefeller University, New York, New York 10021.
Am J Physiol. 1994 Oct;267(4 Pt 2):R974-83. doi: 10.1152/ajpregu.1994.267.4.R974.
The vestibular system is involved in maintaining stable blood pressure and respiration during changes in posture and is essential for eliciting motion sickness-related vomiting. Because the nucleus tractus solitarius (NTS) participates in the regulation of sympathetic and inspiratory outflow and the triggering of emesis, we tested the hypothesis that this region receives vestibular inputs in cats. In one set of experiments, microinjections of the tracer Phaseolus vulgaris leucoagglutinin into the medial and inferior vestibular nuclei labeled projections to the middle and lateral regions of the NTS. In electrophysiological experiments, electrical stimulation of the vestibular nerve modified the firing rates of neurons located in the same regions. Some neurons with vestibular inputs received convergent signals from the abdominal vagus nerve and could potentially mediate motion sickness-related vomiting. Others received convergent baroreceptor inputs and could act as a substrate for some components of vestibulosympathetic reflexes. In contrast, inspiratory neurons in the dorsal respiratory group received little vestibular input, suggesting that vestibulorespiratory reflexes are mediated by cells located elsewhere.
前庭系统在姿势改变时参与维持稳定的血压和呼吸，并且对于引发晕动病相关的呕吐至关重要。由于孤束核（NTS）参与交感神经和吸气输出的调节以及呕吐的触发，我们测试了这一区域在猫中接受前庭输入的假说。在一组实验中，将示踪剂菜豆白细胞凝集素微量注射到内侧和下前庭核中，标记了到NTS中部和外侧区域的投射。在电生理实验中，前庭神经的电刺激改变了位于相同区域的神经元的放电频率。一些接受前庭输入的神经元从前腹迷走神经接收汇聚信号，并可能介导晕动病相关的呕吐。其他神经元接受压力感受器的汇聚输入，并可能作为前庭交感反射某些成分的底物。相比之下，背侧呼吸组中的吸气神经元接受的前庭输入很少，这表明前庭呼吸反射由其他部位的细胞介导。
