Osipova N A, Sviridov S V
Anesteziol Reanimatol. 1993 Mar-Apr(2):3-9.
The expediency of introducing prostaglandin- and kininogenesis inhibitors (acelysin and kontrykal) into general anesthesia and postoperative analgesia has been substantiated and the advantages of the application of these specific nonopiate components of surgical analgesia have been shown. The above inhibitors alleviate local and general homeostasis disorders associated with excessive production of prostaglandins and kinins during surgical trauma and increase the efficacy of analgesia, reducing the need in narcotic analgesics.
将前列腺素和激肽生成抑制剂（阿塞利辛和抑肽酶）用于全身麻醉和术后镇痛的合理性已得到证实，并且已显示出应用这些手术镇痛的特定非阿片类成分的优势。上述抑制剂可缓解与手术创伤期间前列腺素和激肽过度产生相关的局部和全身内环境稳态紊乱，并提高镇痛效果，减少对麻醉性镇痛药的需求。
