Todokoro K, Sugiyama M, Nishida E, Nakaya K
Tsukuba Life Science Center, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan.
Biochem Biophys Res Commun. 1994 Sep 30;203(3):1912-9. doi: 10.1006/bbrc.1994.2411.
Erythropoietin is a cytokine which specifically regulates differentiation and proliferation of erythroid progenitor cells. We show here that binding of erythropoietin to its receptor induced activation of protein tyrosine kinases including Jak2, and of Ras, Raf-1, mitogen-activated protein (MAP) kinase kinase and MAP kinases (ERK1 and ERK2). Taken together with other observations, erythropoietin receptor-mediated signal activates MAP kinase cascade, which is the common signaling pathway activated by other cytokines and growth factor receptors with tyrosine kinase activity.
促红细胞生成素是一种细胞因子，它特异性地调节红系祖细胞的分化和增殖。我们在此表明，促红细胞生成素与其受体的结合诱导了包括Jak2在内的蛋白酪氨酸激酶以及Ras、Raf-1、丝裂原活化蛋白（MAP）激酶激酶和MAP激酶（ERK1和ERK2）的激活。与其他观察结果一起，促红细胞生成素受体介导的信号激活了MAP激酶级联反应，这是由其他具有酪氨酸激酶活性的细胞因子和生长因子受体激活的共同信号通路。
