重组人粒细胞集落刺激因子动员的外周血干细胞用于异基因移植的潜在益处。 - Suppr | 超能文献

Potential benefit of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood stem cells for allogeneic transplantation.

作者信息

Tanaka J, Imamura M, Zhu X, Kobayashi S, Imai K, Hashino S, Sakurada K, Kasai M, Higa T

出版信息

Blood. 1994 Nov 15;84(10):3595-6.

Abstract

摘要

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Potential benefit of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood stem cells for allogeneic transplantation.重组人粒细胞集落刺激因子动员的外周血干细胞用于异基因移植的潜在益处。

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Rapid and sustained allogeneic transplantation using immunoselected CD34(+)-selected peripheral blood progenitor cells mobilized by recombinant granulocyte- and granulocyte-macrophage colony-stimulating factors.使用重组粒细胞集落刺激因子和粒细胞巨噬细胞集落刺激因子动员的免疫选择的CD34(+)选择外周血祖细胞进行快速且持续的同种异体移植。

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Treatment of poor marrow graft function with allogeneic CD34+ cells immunoselected from G-CSF-mobilized peripheral blood progenitor cells of the marrow donor.采用从骨髓供体的粒细胞集落刺激因子动员的外周血祖细胞中免疫分选的同种异体CD34+细胞治疗骨髓移植功能不良。

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Successful autografting following myeloablative conditioning therapy with blood stem cells mobilized by chemotherapy plus rhG-CSF.采用化疗加重组人粒细胞集落刺激因子动员的血液干细胞进行清髓性预处理治疗后成功进行自体移植。

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Successful engraftment of T-cell-depleted haploidentical "three-loci" incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum.通过在骨髓接种物中添加重组人粒细胞集落刺激因子动员的外周血祖细胞，成功实现了T细胞去除的单倍体相合“三位点”不相合移植在白血病患者中的植入。

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Ex vivo expansion of enriched peripheral blood CD34+ progenitor cells by stem cell factor, interleukin-1 beta (IL-1 beta), IL-6, IL-3, interferon-gamma, and erythropoietin.通过干细胞因子、白细胞介素-1β（IL-1β）、IL-6、IL-3、干扰素-γ和促红细胞生成素对富集的外周血CD34+祖细胞进行体外扩增。

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Granulocyte-colony stimulating factor drives the in vitro differentiation of human dendritic cells that induce anergy in naïve T cells.粒细胞集落刺激因子驱动体外人树突状细胞分化，诱导幼稚 T 细胞失能。

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Clinical application of allogeneic peripheral blood stem cells transplantation.

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