Sardaş S, Erdoğan F, Sardaş O S, Cengel M, Karakaya A E
Department of Toxicology, Gazi University, Faculty of Pharmacy, Ankara, Turkey.
Anticancer Drugs. 1994 Aug;5(4):487-9.
Sister chromatid exchange (SCE) frequencies were studied in lymphocytes from 45 patients with malignant lymphoma. Fifteen patients were untreated when studied. The mean SCE frequency for these patients was 8.70 +/- 0.99 per mitosis. The mean score for 35 controls was 4.37 +/- 1.19. SCE mean scores were significantly higher in the untreated patients than in the controls (p < 0.001). Nine patients were treated with radiotherapy alone. The mean SCE frequency (6.80 +/- 0.87) they demonstrated was significantly lower (p < 0.01) than that found in untreated patients. Twelve patients received cyclophosphamide 1 month before the study was started. They demonstrated a mean SCE frequency (12.00 +/- 1.31) significantly higher (p < 0.05) than that found in patients who had received regimens that did not contain cyclophosphamide (9.72 +/- 1.32). From these findings we suggest that untreated patients with malignant lymphoma have elevated SCE frequencies, which may be further increased by chemotherapeutic agents.
对45例恶性淋巴瘤患者淋巴细胞中的姐妹染色单体交换（SCE）频率进行了研究。研究时15例患者未接受治疗。这些患者的平均SCE频率为每有丝分裂8.70±0.99。35名对照者的平均分数为4.37±1.19。未治疗患者的SCE平均分数显著高于对照者（p<0.001）。9例患者仅接受放射治疗。他们表现出的平均SCE频率（6.80±0.87）显著低于未治疗患者（p<0.01）。12例患者在研究开始前1个月接受了环磷酰胺治疗。他们表现出的平均SCE频率（12.00±1.31）显著高于未接受含环磷酰胺治疗方案的患者（9.72±1.32）（p<0.05）。根据这些发现，我们认为未治疗的恶性淋巴瘤患者SCE频率升高，化疗药物可能会使其进一步升高。
