Matsuoka S
Department of Pediatrics, Tokushima University.
Nihon Koshu Eisei Zasshi. 1994 Sep;41(9):933-7.
To detect chronic hepatitis C virus infection in recipients of blood products.
Retrospective analysis by recall and enrollment of recipients.
Two-hundred twenty-six patients who received blood products in Tokushima for open heart surgery from January 1993 to December 1992 were examined for HCV antibodies by second-generation assay and surrogate markers.
Twenty two (14%) of the 161 patients who received blood products before Nov 1989 had detectable HCV antibodies, but none of the 65 recipients receiving blood after 1990, the year the blood bank began to screen for HCV-antibody. Of 22 seropositive patients, HCV RNA (ribonucleic acid) was recognized in 10 (45%) by HCV PCR (polymerase chain reaction) method, indicating persistent HCV infection. Moreover, abnormal alanine aminotransferase (ALT), more than 25 IU/l, during the chronic phase of HCV infection was recognized in 9 of 10 patients with detectable HCV RNA, but none in patients with undetectable HCV RNA. In the 15 patients in whom liver biopsy was performed, 10 had abnormal histology; 4 chronic active hepatitis, 6 chronic persistent hepatitis, and 5 had normal histology.
It is Important to recall and screen for chronic hepatitis C In blood product recipients, since persistent and active HCV infection is often assymptomatic, yet treatable.
检测血液制品接受者中的慢性丙型肝炎病毒感染情况。
通过对接受者进行回顾性分析及登记入组。
对1992年1月至1993年12月在德岛接受心脏直视手术的226例血液制品接受者，采用第二代检测方法及替代标志物检测丙型肝炎病毒抗体。
在1989年11月之前接受血液制品的161例患者中，22例（14%）检测到丙型肝炎病毒抗体，但在1990年血库开始筛查丙型肝炎病毒抗体之后接受血液制品的65例接受者中，无一例检测到抗体。在22例血清学阳性患者中，采用丙型肝炎病毒聚合酶链反应（HCV PCR）方法，10例（45%）检测到丙型肝炎病毒核糖核酸（HCV RNA），表明存在持续性丙型肝炎病毒感染。此外，在10例检测到丙型肝炎病毒RNA的患者中，9例在丙型肝炎病毒感染慢性期丙氨酸转氨酶（ALT）异常（超过25 IU/l），而在未检测到丙型肝炎病毒RNA的患者中无一例异常。在接受肝活检的15例患者中，10例组织学异常；4例为慢性活动性肝炎，6例为慢性持续性肝炎，5例组织学正常。
对血液制品接受者进行慢性丙型肝炎的回顾性筛查很重要，因为持续性和活动性丙型肝炎病毒感染通常无症状，但可治疗。
