Matsuoka S, Tatara K, Hayabuchi Y, Nii M, Mori K, Kuroda Y
Department of Pediatrics, University of Tokushima, School of Medicine, Japan.
J Paediatr Child Health. 1994 Dec;30(6):544-6. doi: 10.1111/j.1440-1754.1994.tb00731.x.
Two hundred and twenty-six patients who received blood products for open-heart surgery in childhood were screened by a second-generation enzyme-linked immunosorbent assay and with surrogate markers for hepatitis C virus (HCV) infection, such as alanine aminotransferase (ALT). Twenty-two (14%) of the 161 recipients who received blood products before 1989 and none of the subjects who had received blood products after 1990 (the year that the blood bank began to screen for HCV antibody) were HCV seropositive. Virologic and histologic studies showed that 10 (45%) of 24 seropositive patients had persistent hepatitis C virus infection, many with ongoing hepatitis. The remaining 12 seropositive patients with absent HCV RNA had normal ALT levels, indicating resolved hepatitis C infection. Enrolment in screening is important to detect chronic hepatitis C in children who received blood products prior to screening of blood donors for HCV antibody.
对226名曾在儿童期接受心脏直视手术输血制品的患者，采用第二代酶联免疫吸附试验以及丙氨酸氨基转移酶（ALT）等丙型肝炎病毒（HCV）感染替代标志物进行筛查。在1989年之前接受输血制品的161名受血者中，有22人（14%）HCV血清学呈阳性，而在1990年（血库开始筛查HCV抗体的年份）之后接受输血制品的受试者中无人HCV血清学呈阳性。病毒学和组织学研究显示，24名血清学呈阳性的患者中有10人（45%）存在持续性丙型肝炎病毒感染，其中许多人伴有持续性肝炎。其余12名HCV RNA阴性的血清学呈阳性患者ALT水平正常，表明丙型肝炎感染已消退。开展筛查对于检测在献血者筛查HCV抗体之前接受输血制品的儿童中的慢性丙型肝炎很重要。
