Genetic analyses of cell-matrix interactions in development.
作者信息
Hynes R O
机构信息
Howard Hughes Medical Institute and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139.
出版信息
Curr Opin Genet Dev. 1994 Aug;4(4):569-74. doi: 10.1016/0959-437x(94)90074-d.
PMID:7524834
Abstract
The extracellular matrix and its cell surface receptors are thought to be important in development. Recent applications of targeted mutagenesis in mice have begun to test hypotheses based on in vitro data and patterns of expression. 'Knockout' mutations of matrix molecules and integrins reveal complexities arising from multiple receptors and ligands.
摘要
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