Zhang X L, Shi J Q, Zuo S H
Department of Pathology, Third Military Medical College, Chongqing.
Zhonghua Bing Li Xue Za Zhi. 1994;23(3):155-8.
The expression of P21, AFP and CEA were detected in human hepatocellular carcinoma and its surrounding nontumor tissues by immunohistochemical staining on serial sections. The significance of AFP and P21 in HCC auxiliary diagnosis was discussed. The results are as follows: (1) AFP and P21 were more closely related with HCC than CEA. Both AFP and P21 were expressed simultaneously in more than half the cases. The distribution of these two antigens in HCC was similar. (2) The positive incidence of AFP in tumor tissues was higher than that in surrounding nontumor tissues, but vice versa for P21. Based on the results of this study, we regard that AFP is a relatively specific marker of HCC, better than P21 in auxiliary diagnosis of HCC. The hepatocytes which surround the tumor and can simultaneously express AFP and P21, are likely to be precancerous cells which have been initiated and possess the ability of neoplastic growth but lack phenotype transformation.
通过对连续切片进行免疫组织化学染色，检测人肝细胞癌及其周围非肿瘤组织中P21、甲胎蛋白（AFP）和癌胚抗原（CEA）的表达情况。探讨了AFP和P21在肝癌辅助诊断中的意义。结果如下：（1）与CEA相比，AFP和P21与肝癌的关系更为密切。超过半数病例中AFP和P21同时表达。这两种抗原在肝癌中的分布相似。（2）肿瘤组织中AFP的阳性发生率高于周围非肿瘤组织，但P21的情况则相反。基于本研究结果，我们认为AFP是肝癌相对特异的标志物，在肝癌辅助诊断方面优于P21。肿瘤周围能同时表达AFP和P21的肝细胞，可能是已启动且具有肿瘤生长能力但缺乏表型转化的癌前细胞。
