人类水通道蛋白2（AQP2）基因和主要内在蛋白（MIP）基因是MIP家族的两个成员，基于双色荧光原位杂交（FISH）技术，它们定位于12号染色体q13区带。
Human AQP2 and MIP genes, two members of the MIP family, map within chromosome band 12q13 on the basis of two-color FISH.
作者信息
Saito F, Sasaki S, Chepelinsky A B, Fushimi K, Marumo F, Ikeuchi T
机构信息
Department of Cytogenetics, Tokyo Medical and Dental University, Japan.
出版信息
Cytogenet Cell Genet. 1995;68(1-2):45-8. doi: 10.1159/000133885.
The human AQP2 (collecting duct water channel, aquaporin 2) gene encodes a 271 amino acid protein and is a member of the MIP (major intrinsic protein of lens fiber) gene family. Using two-color fluorescence in situ hybridization on high-resolution R-banded chromosomes and human genomic DNA clones for AQP2 and MIP as probes, we found that both genes mapped closely within the human chromosome region 12q13.
人类水通道蛋白2（集合管水通道，水通道蛋白2）基因编码一种含271个氨基酸的蛋白质，是MIP（晶状体纤维主要内在蛋白）基因家族的成员。我们使用高分辨率R带染色体上的双色荧光原位杂交技术，并以水通道蛋白2和MIP的人类基因组DNA克隆作为探针，发现这两个基因在人类染色体区域12q13内紧密定位。
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