Caccia M R, Mangili A, Mecca G, Ubiali E, Zanoni P
J Neurol. 1977 Dec 13;217(2):123-31. doi: 10.1007/BF00312925.
The involvement of peripheral motor and sensory nerve, at least on a subclinical level, is nearly constant event with chronic renal failure. The study of the motor and sensory propagation velocity indicates that a widespread functional lesion of the axon with a peripheral point of attack and secondary demyelination, may be the basic pathogenetic event of uremic polyneuropathy. Prolonged hemodialytic treatment is substantially unable to influence the evolution of uremic polyneuropathy. The electrophysiological follow-up study of the peripheral nerve does not seem to be an index of adequate dialysis.
外周运动和感觉神经受累，至少在亚临床水平上，是慢性肾衰竭几乎持续存在的情况。运动和感觉神经传导速度的研究表明，轴突存在广泛的功能性病变，起始于外周并继发脱髓鞘，可能是尿毒症性多发性神经病的基本发病机制。长期血液透析治疗基本上无法影响尿毒症性多发性神经病的进展。外周神经的电生理随访研究似乎并不是充分透析的指标。
