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载脂蛋白E（ApoE），一种新型肝素结合蛋白，可抑制BALB/c裸鼠卡波西肉瘤样病变的发展。

Apolipoprotein E (ApoE), a novel heparin-binding protein inhibits the development of Kaposi's sarcoma-like lesions in BALB/c nu/nu mice.

作者信息

Browning P J, Roberts D D, Zabrenetzky V, Bryant J, Kaplan M, Washington R H, Panet A, Gallo R C, Vogel T

机构信息

Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.

出版信息

J Exp Med. 1994 Nov 1;180(5):1949-54. doi: 10.1084/jem.180.5.1949.

DOI:10.1084/jem.180.5.1949
PMID:7525844
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2191722/
Abstract

Recombinant apolipoprotein E-3 (ApoE-3), expressed in Escherichia coli, was purified and used in an in vitro and an in vivo model system for acquired immunodeficiency syndrome-associated Kaposi's sarcoma (AIDS-KS). This protein blocked cell proliferation and chemotaxis of AIDS-KS cells in response to activated lymphocyte conditioned medium (AL-CM) and oncostatin M (OSM). ApoE-3 also inhibited the formation of neoangiogenic lesions induced in BALB/c nu/nu mice by AIDS-KS cells. These findings represent a novel and potentially less toxic therapeutic approach for the treatment of AIDS-KS.

摘要

在大肠杆菌中表达的重组载脂蛋白E-3（ApoE-3）被纯化，并用于获得性免疫缺陷综合征相关卡波西肉瘤（AIDS-KS）的体外和体内模型系统。该蛋白可阻断AIDS-KS细胞对活化淋巴细胞条件培养基（AL-CM）和抑瘤素M（OSM）的细胞增殖和趋化作用。ApoE-3还可抑制AIDS-KS细胞在BALB/c裸鼠中诱导形成的新生血管性病变。这些发现代表了一种治疗AIDS-KS的新的且潜在毒性较小的治疗方法。

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Apolipoprotein E (ApoE), a novel heparin-binding protein inhibits the development of Kaposi's sarcoma-like lesions in BALB/c nu/nu mice.载脂蛋白E（ApoE），一种新型肝素结合蛋白，可抑制BALB/c裸鼠卡波西肉瘤样病变的发展。
J Exp Med. 1994 Nov 1;180(5):1949-54. doi: 10.1084/jem.180.5.1949.
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本文引用的文献

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The hypertriglyceridemia of acquired immunodeficiency syndrome is associated with an increased prevalence of low density lipoprotein subclass pattern B.获得性免疫缺陷综合征的高甘油三酯血症与低密度脂蛋白B亚类模式患病率增加有关。
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Oncostatin M is a mitogen for rabbit vascular smooth muscle cells.抑瘤素M是兔血管平滑肌细胞的促有丝分裂原。
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Inhibitory effects of a bacteria-derived sulfated polysaccharide against basic fibroblast growth factor-induced endothelial cell growth and chemotaxis.一种细菌来源的硫酸化多糖对碱性成纤维细胞生长因子诱导的内皮细胞生长和趋化性的抑制作用。
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Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation.细胞外1型人类免疫缺陷病毒Tat蛋白的释放、摄取及其对细胞生长和病毒反式激活的影响
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