载脂蛋白E（ApoE），一种新型肝素结合蛋白，可抑制BALB/c裸鼠卡波西肉瘤样病变的发展。
Apolipoprotein E (ApoE), a novel heparin-binding protein inhibits the development of Kaposi's sarcoma-like lesions in BALB/c nu/nu mice.
作者信息
Browning P J, Roberts D D, Zabrenetzky V, Bryant J, Kaplan M, Washington R H, Panet A, Gallo R C, Vogel T
机构信息
Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
出版信息
J Exp Med. 1994 Nov 1;180(5):1949-54. doi: 10.1084/jem.180.5.1949.
Abstract
Recombinant apolipoprotein E-3 (ApoE-3), expressed in Escherichia coli, was purified and used in an in vitro and an in vivo model system for acquired immunodeficiency syndrome-associated Kaposi's sarcoma (AIDS-KS). This protein blocked cell proliferation and chemotaxis of AIDS-KS cells in response to activated lymphocyte conditioned medium (AL-CM) and oncostatin M (OSM). ApoE-3 also inhibited the formation of neoangiogenic lesions induced in BALB/c nu/nu mice by AIDS-KS cells. These findings represent a novel and potentially less toxic therapeutic approach for the treatment of AIDS-KS.
摘要
在大肠杆菌中表达的重组载脂蛋白E-3（ApoE-3）被纯化，并用于获得性免疫缺陷综合征相关卡波西肉瘤（AIDS-KS）的体外和体内模型系统。该蛋白可阻断AIDS-KS细胞对活化淋巴细胞条件培养基（AL-CM）和抑瘤素M（OSM）的细胞增殖和趋化作用。ApoE-3还可抑制AIDS-KS细胞在BALB/c裸鼠中诱导形成的新生血管性病变。这些发现代表了一种治疗AIDS-KS的新的且潜在毒性较小的治疗方法。
相似文献
1
Apolipoprotein E (ApoE), a novel heparin-binding protein inhibits the development of Kaposi's sarcoma-like lesions in BALB/c nu/nu mice.载脂蛋白E（ApoE），一种新型肝素结合蛋白，可抑制BALB/c裸鼠卡波西肉瘤样病变的发展。
J Exp Med. 1994 Nov 1;180(5):1949-54. doi: 10.1084/jem.180.5.1949.
2
Block of AIDS-Kaposi's sarcoma (KS) cell growth, angiogenesis, and lesion formation in nude mice by antisense oligonucleotide targeting basic fibroblast growth factor. A novel strategy for the therapy of KS.通过靶向碱性成纤维细胞生长因子的反义寡核苷酸阻断艾滋病相关卡波西肉瘤（KS）细胞生长、血管生成及裸鼠体内病损形成。一种治疗KS的新策略。
J Clin Invest. 1994 Nov;94(5):1736-46. doi: 10.1172/JCI117521.
3
Inhibition of development of Kaposi's sarcoma-related lesions by a bacterial cell wall complex.一种细菌细胞壁复合物对卡波西肉瘤相关病变发展的抑制作用。
Science. 1992 Mar 13;255(5050):1437-40. doi: 10.1126/science.1371891.
4
Angiogenic potential in vivo by Kaposi's sarcoma cell-free supernatants and HIV-1 tat product: inhibition of KS-like lesions by tissue inhibitor of metalloproteinase-2.卡波西肉瘤无细胞上清液和HIV-1 tat产物在体内的血管生成潜力：金属蛋白酶组织抑制剂-2对卡波西肉瘤样病变的抑制作用
AIDS. 1994 Sep;8(9):1237-44. doi: 10.1097/00002030-199409000-00004.
5
Inhibition of AIDS-Kaposi's sarcoma cell proliferation following retinoic acid receptor activation.维甲酸受体激活后对艾滋病-卡波西肉瘤细胞增殖的抑制作用。
Cancer Res. 1995 Feb 15;55(4):823-9.
6
7
8
9
Involvement of vascular endothelial growth factor in Kaposi's sarcoma associated with acquired immunodeficiency syndrome.血管内皮生长因子与获得性免疫缺陷综合征相关的卡波西肉瘤的关系。
Jpn J Cancer Res. 1996 Nov;87(11):1143-52. doi: 10.1111/j.1349-7006.1996.tb03124.x.
10
Sustained angiogenesis enables in vivo transplantation of mucocutaneous derived AIDS-related Kaposi's sarcoma cells in murine hosts.持续的血管生成能够使源自黏膜皮肤的艾滋病相关卡波西肉瘤细胞在小鼠宿主体内进行移植。
Carcinogenesis. 2000 Sep;21(9):1647-53. doi: 10.1093/carcin/21.9.1647.
引用本文的文献
1
Extracellular vesicles released by human retinal pigment epithelium mediate increased polarised secretion of drusen proteins in response to AMD stressors.人视网膜色素上皮细胞释放的细胞外囊泡介导 AMD 应激下 drusen 蛋白的极化分泌增加。
J Extracell Vesicles. 2021 Nov;10(13):e12165. doi: 10.1002/jev2.12165.
2
Association between apolipoprotein E genotype and cancer susceptibility: a meta-analysis.载脂蛋白E基因多态性与癌症易感性的关联：一项荟萃分析。
J Cancer Res Clin Oncol. 2014 Jul;140(7):1075-85. doi: 10.1007/s00432-014-1634-2. Epub 2014 Apr 5.
3
Dual action of apolipoprotein E-interacting HCCR-1 oncoprotein and its implication for breast cancer and obesity.载脂蛋白 E 相互作用 HCCR-1 癌蛋白的双重作用及其对乳腺癌和肥胖的影响。
J Cell Mol Med. 2009 Sep;13(9B):3868-75. doi: 10.1111/j.1582-4934.2009.00652.x.
4
Association of apolipoprotein E polymorphisms and dietary factors in colorectal cancer.载脂蛋白E基因多态性与结直肠癌饮食因素的关联
Br J Cancer. 2009 Jun 16;100(12):1966-74. doi: 10.1038/sj.bjc.6605097. Epub 2009 May 19.
5
Malignant fibrous histiocytoma--pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study.恶性纤维组织细胞瘤--多形性肉瘤，NOS 基因表达、组织学和临床过程。一项初步研究。
Langenbecks Arch Surg. 2010 Mar;395(3):261-75. doi: 10.1007/s00423-009-0465-0. Epub 2009 Jan 22.
6
Progress toward identification of protease activity involved in proteolysis of apolipoprotein e in human brain.在鉴定参与人脑中载脂蛋白E蛋白水解的蛋白酶活性方面取得的进展。
J Mol Neurosci. 2004;24(1):73-80. doi: 10.1385/JMN:24:1:073.
7
Apolipoprotein E-related neurotoxicity as a therapeutic target for Alzheimer's disease.载脂蛋白E相关神经毒性作为阿尔茨海默病的治疗靶点
J Mol Neurosci. 2003;20(3):327-37. doi: 10.1385/JMN:20:3:327.
本文引用的文献
1
The hypertriglyceridemia of acquired immunodeficiency syndrome is associated with an increased prevalence of low density lipoprotein subclass pattern B.获得性免疫缺陷综合征的高甘油三酯血症与低密度脂蛋白B亚类模式患病率增加有关。
J Clin Endocrinol Metab. 1993 Jun;76(6):1423-7. doi: 10.1210/jcem.76.6.8501146.
2
The pathogenesis of atherosclerosis: a perspective for the 1990s.动脉粥样硬化的发病机制：20世纪90年代的展望
Nature. 1993 Apr 29;362(6423):801-9. doi: 10.1038/362801a0.
3
Oncostatin M is a mitogen for rabbit vascular smooth muscle cells.抑瘤素M是兔血管平滑肌细胞的促有丝分裂原。
Proc Natl Acad Sci U S A. 1993 Feb 1;90(3):823-7. doi: 10.1073/pnas.90.3.823.
4
Inhibitory effects of a bacteria-derived sulfated polysaccharide against basic fibroblast growth factor-induced endothelial cell growth and chemotaxis.一种细菌来源的硫酸化多糖对碱性成纤维细胞生长因子诱导的内皮细胞生长和趋化性的抑制作用。
J Cell Physiol. 1993 Jan;154(1):1-6. doi: 10.1002/jcp.1041540102.
5
Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation.细胞外1型人类免疫缺陷病毒Tat蛋白的释放、摄取及其对细胞生长和病毒反式激活的影响
J Virol. 1993 Jan;67(1):277-87. doi: 10.1128/JVI.67.1.277-287.1993.
6
Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.人载脂蛋白E与合成β淀粉样肽的结合：异构体特异性效应及其对晚发性阿尔茨海默病的意义
Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8098-102. doi: 10.1073/pnas.90.17.8098.
7
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.载脂蛋白E4等位基因的基因剂量与晚发型家族性阿尔茨海默病的风险
Science. 1993 Aug 13;261(5123):921-3. doi: 10.1126/science.8346443.
8
Modulation of endothelial cell proliferation, adhesion, and motility by recombinant heparin-binding domain and synthetic peptides from the type I repeats of thrombospondin.重组血小板反应蛋白I型重复序列的肝素结合域及合成肽对内皮细胞增殖、黏附和迁移的调节作用
J Cell Biochem. 1993 Sep;53(1):74-84. doi: 10.1002/jcb.240530109.
9
10
Recombinant alpha-2 interferon therapy for Kaposi's sarcoma associated with the acquired immunodeficiency syndrome.重组α-2干扰素治疗与获得性免疫缺陷综合征相关的卡波西肉瘤。
Ann Intern Med. 1984 May;100(5):671-6. doi: 10.7326/0003-4819-100-5-671.
Zotero 插件