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1
Involvement of vascular endothelial growth factor in Kaposi's sarcoma associated with acquired immunodeficiency syndrome.血管内皮生长因子与获得性免疫缺陷综合征相关的卡波西肉瘤的关系。
Jpn J Cancer Res. 1996 Nov;87(11):1143-52. doi: 10.1111/j.1349-7006.1996.tb03124.x.
2
Vascular endothelial growth factor and basic fibroblast growth factor present in Kaposi's sarcoma (KS) are induced by inflammatory cytokines and synergize to promote vascular permeability and KS lesion development.卡波西肉瘤（KS）中存在的血管内皮生长因子和碱性成纤维细胞生长因子由炎性细胞因子诱导产生，并协同作用以促进血管通透性和卡波西肉瘤病变发展。
Am J Pathol. 1998 Jun;152(6):1433-43.
3
Vascular endothelial growth factor regulates angiogenesis and vascular permeability in Kaposi's sarcoma.血管内皮生长因子调节卡波西肉瘤中的血管生成和血管通透性。
Am J Pathol. 1996 Dec;149(6):1851-69.
4
Vascular endothelial growth factor is a potent angiogenic factor in AIDS-associated Kaposi's sarcoma-derived spindle cells.血管内皮生长因子是艾滋病相关卡波西肉瘤来源的梭形细胞中一种有效的血管生成因子。
J Immunol. 1997 May 15;158(10):4992-5001.
5
Kaposi's sarcoma cells of different etiologic origins respond to HIV-Tat through the Flk-1/KDR (VEGFR-2): relevance in AIDS-KS pathology.不同病因起源的卡波西肉瘤细胞通过Flk-1/KDR（血管内皮生长因子受体2）对HIV-Tat作出反应：在艾滋病相关卡波西肉瘤病理学中的意义
Biochem Biophys Res Commun. 2000 Jun 24;273(1):267-71. doi: 10.1006/bbrc.2000.2941.
6
Strong expression of kinase insert domain-containing receptor, a vascular permeability factor/vascular endothelial growth factor receptor in AIDS-associated Kaposi's sarcoma and cutaneous angiosarcoma.含激酶插入结构域受体（一种血管通透性因子/血管内皮生长因子受体）在艾滋病相关卡波西肉瘤和皮肤血管肉瘤中呈强表达。
Am J Pathol. 1996 Apr;148(4):1065-74.
7
The role of vascular endothelial growth factor (VEGF) in AIDS-related Kaposi's sarcoma.血管内皮生长因子（VEGF）在艾滋病相关卡波西肉瘤中的作用。
Oncologist. 2000;5 Suppl 1:28-31. doi: 10.1634/theoncologist.5-suppl_1-28.
8
Inflammatory cytokines synergize with the HIV-1 Tat protein to promote angiogenesis and Kaposi's sarcoma via induction of basic fibroblast growth factor and the alpha v beta 3 integrin.炎症细胞因子与HIV-1 Tat蛋白协同作用，通过诱导碱性成纤维细胞生长因子和αvβ3整合素来促进血管生成和卡波西肉瘤。
J Immunol. 1999 Aug 15;163(4):1929-35.
9
Vascular endothelial growth factor/vascular permeability factor is an autocrine growth factor for AIDS-Kaposi sarcoma.血管内皮生长因子/血管通透因子是艾滋病相关卡波西肉瘤的一种自分泌生长因子。
Proc Natl Acad Sci U S A. 1997 Feb 4;94(3):979-84. doi: 10.1073/pnas.94.3.979.
10
Supernatants of acquired immunodeficiency syndrome-related Kaposi's sarcoma cells induce endothelial cell chemotaxis and invasiveness.获得性免疫缺陷综合征相关卡波西肉瘤细胞的上清液可诱导内皮细胞趋化性和侵袭性。
Cancer Res. 1991 May 15;51(10):2670-6.

本文引用的文献

1
Some clinical aspects of Kaposi's sarcoma in the European and North American populations.欧洲和北美人群中卡波西肉瘤的一些临床方面
Acta Unio Int Contra Cancrum. 1962;18:364-71.
2
ENDOGENEOUS PERMEABILITY FACTORS AND THEIR INHIBITORS AFFECTING VASCULAR PERMEABILITY IN CUTANEOUS ARTHUS REACTIONS AND THERMAL INJURY.内源性通透性因子及其抑制剂对皮肤Arthus反应和热损伤中血管通透性的影响
Br J Exp Pathol. 1964 Aug;45(4):419-35.
3
Vascular reactions to histamine, histamine-liberator and leukotaxine in the skin of guinea-pigs.组胺、组胺释放剂和白细胞趋化因子对豚鼠皮肤的血管反应
J Physiol. 1952 Oct;118(2):228-57. doi: 10.1113/jphysiol.1952.sp004789.
4
Cooperative effect of TNFalpha, bFGF, and VEGF on the formation of tubular structures of human microvascular endothelial cells in a fibrin matrix. Role of urokinase activity.肿瘤坏死因子α、碱性成纤维细胞生长因子和血管内皮生长因子在纤维蛋白基质中对人微血管内皮细胞管状结构形成的协同作用。尿激酶活性的作用。
J Cell Biol. 1996 Mar;132(6):1177-88. doi: 10.1083/jcb.132.6.1177.
5
Correlation of oncostatin M secretion by human retrovirus-infected cells with potent growth stimulation of cultured spindle cells from AIDS-Kaposi's sarcoma.人类逆转录病毒感染细胞分泌的抑瘤素M与艾滋病相关卡波西肉瘤培养的梭形细胞的强效生长刺激之间的相关性。
J Immunol. 1993 Jun 1;150(11):5195-201.
6
Expression of adhesion molecules, platelet-activating factor, and chemokines by Kaposi's sarcoma cells.卡波西肉瘤细胞中黏附分子、血小板活化因子及趋化因子的表达
J Immunol. 1994 Nov 15;153(10):4816-25.
7
The detection of acquired immunodeficiency syndrome-associated Kaposi sarcoma cells in pleural effusion by CD34 immunostain.通过CD34免疫染色检测胸腔积液中获得性免疫缺陷综合征相关的卡波西肉瘤细胞。
Cancer. 1993 Oct 1;72(7):2260-5. doi: 10.1002/1097-0142(19931001)72:7<2260::aid-cncr2820720733>3.0.co;2-9.
8
Synthesis and assembly of functionally active human vascular endothelial growth factor homodimers in insect cells.在昆虫细胞中合成与组装具有功能活性的人血管内皮生长因子同型二聚体。
Eur J Biochem. 1993 Jan 15;211(1-2):19-26. doi: 10.1111/j.1432-1033.1993.tb19865.x.
9
Kaposi's sarcoma: clinical features, experience in Uganda.
Antibiot Chemother (1971). 1981;29:59-67. doi: 10.1159/000397440.
10
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.肿瘤细胞分泌一种血管通透性因子，可促进腹水的积聚。
Science. 1983 Feb 25;219(4587):983-5. doi: 10.1126/science.6823562.

血管内皮生长因子与获得性免疫缺陷综合征相关的卡波西肉瘤的关系。

Involvement of vascular endothelial growth factor in Kaposi's sarcoma associated with acquired immunodeficiency syndrome.

作者信息

Sakurada S, Kato T, Mashiba K, Mori S, Okamoto T

机构信息

Department of Molecular Genetics, Nagoya City University Medical School, Mizuho-ku.

出版信息

Jpn J Cancer Res. 1996 Nov;87(11):1143-52. doi: 10.1111/j.1349-7006.1996.tb03124.x.

DOI:10.1111/j.1349-7006.1996.tb03124.x
PMID:9045943
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5921004/
Abstract

To examine the role of vascular endothelial growth factor (VEGF) in the development of edema associated with Kaposi's sarcoma (KS) in acquired immunodeficiency syndrome (AIDS), we exploited animal model systems to detect the activity that induces vascular hyper-permeability (VHP) using cultured AIDS-KS spindle cells. Cultured AIDS-KS spindle cells and conditioned medium (AIDS-KS-CM) that had been semi-purified through a heparin affinity column were tested for the ability to induce VHP in animals. The AIDS-KS spindle cells and AIDS-KS-CM induced VHP that was histamine-independent. The VHP-inducing activity was detected in the 0.5 M NaCl fraction from the heparin affinity column and was blocked by anti-VEGF neutralizing antibody. In addition, the production of VEGF was demonstrated in fresh AIDS-KS tissue as well as in cultured AIDS-KS cells, while control cells were negative for VEGF production. From these observations, we concluded that AIDS-KS cells produce a factor(s) that promotes VHP, and this factor could be VEGF.

摘要

为研究血管内皮生长因子（VEGF）在获得性免疫缺陷综合征（AIDS）相关的卡波西肉瘤（KS）水肿形成中的作用，我们利用动物模型系统，通过培养的AIDS-KS梭形细胞检测诱导血管高通透性（VHP）的活性。检测培养的AIDS-KS梭形细胞和经肝素亲和柱半纯化的条件培养基（AIDS-KS-CM）在动物体内诱导VHP的能力。AIDS-KS梭形细胞和AIDS-KS-CM诱导的VHP与组胺无关。在肝素亲和柱的0.5M NaCl组分中检测到VHP诱导活性，且该活性被抗VEGF中和抗体阻断。此外，新鲜AIDS-KS组织以及培养的AIDS-KS细胞中均证实有VEGF产生，而对照细胞VEGF产生呈阴性。基于这些观察结果，我们得出结论，AIDS-KS细胞产生促进VHP的一种或多种因子，且该因子可能是VEGF。