Kurbanov R D, Azimova N A, Kiakbaev G K, Abdullaev T A, Asriiants L S, Zakirov N U, Avezov D K, Faĭzullaev B P
Kardiologiia. 1993;33(5):27-9.
Platelet aggregability was studied in 81 patients with prior myocardial infarction with various cardiac arrhythmias and its effects of some antiarrhythmic agents (allapinine, ethacizine, obsidan and cordarone). It was 32-39% higher in patients with frequent ventricular extrasystole (VE) and VE of high grades (4a and 4b by the classification of Lown and Wolt) than in control patients (without arrhythmias) and patients with supraventricular and rare VE. Ethacizine and cordarone produced a significant inhibitory effects on platelet functional activity, but the effects of allapinine and obsidan on this parameter were insignificant. There was no correlation between the magnitude of antiarrhythmic effects of the drugs and their antiaggregatory properties. It was shown that the results of examining the effects of antiarrhythmic agents on platelet aggregability in vitro were not in agreement with those obtained in vivo.
对81例既往有心肌梗死且伴有各种心律失常的患者进行了血小板聚集性研究，并研究了某些抗心律失常药物（阿拉平宁、乙胺碘呋酮、乙吗噻嗪和胺碘酮）对其的影响。频发室性期前收缩（VE）以及高等级VE（根据Lown和Wolt分类为4a和4b级）的患者，其血小板聚集性比对照组患者（无心律失常）以及有室上性和偶发VE的患者高32%-39%。乙吗噻嗪和胺碘酮对血小板功能活性有显著抑制作用，但阿拉平宁和乙胺碘呋酮对该参数的影响不显著。药物的抗心律失常作用大小与其抗聚集特性之间无相关性。结果表明，体外检测抗心律失常药物对血小板聚集性的影响结果与体内获得的结果不一致。
