Khakimov A G, Merkulova I N, Semeĭkin O V, Frolova E P, Mansurova G L, Mazaev A V, Ruda M Ia
Kardiologiia. 1991 Nov;31(11):58-62.
During a prolonged (24-hour) intravenous administration in a dose of 126 mg, allapinine produced a stable pronounced antiarrhythmic effect in 90% of the patients with frequent premature ventricular contraction and adverse reactions in the central nervous system in 65% of the cases. However, the latter effect of allapinine is short-term and ceased independently without altering the infusion rate. More serious adverse effects (hypotensive reactions, proarhythmic effects) occurred in 4% of the cases.
在以126毫克的剂量进行长达24小时的静脉给药过程中，阿拉平宁对90%的频发室性早搏患者产生了稳定且显著的抗心律失常作用，65%的患者出现了中枢神经系统不良反应。然而，阿拉平宁的后一种作用是短期的，且在不改变输注速率的情况下自行停止。4%的病例出现了更严重的不良反应（低血压反应、促心律失常作用）。
