Kumanohoso T, Natsugoe S, Shimada M, Aikou T, Nakamura K, Yamada K, Fukuzaki H
First Department of Surgery, Kagoshima University School of Medicine, Japan.
J Surg Oncol. 1994 Nov;57(3):178-82. doi: 10.1002/jso.2930570308.
The possible usefulness of bleomycin incorporated with biodegradable poly-d, l-lactic acid (BLM-PLA) for targeting chemotherapy for esophageal cancer was studied in vivo. Local levels of BLM after administration were compared with those after injection of BLM-SOL, an aqueous solution of BLM. BLM-PLA or BLM-SOL was administered into the upper mediastinum under a right thoracotomy in 36 mongrel dogs. On days 10, 20, and 30 after administration, connective tissues, lymph nodes, lung, liver, kidney, and spleen were removed, and BLM activity was measured. High activity of BLM was detected for 30 days after BLM-PLA administration in both the connective tissues and the lymph nodes, compared with BLM-SOL administration. BLM activity was low in the other organs after BLM-PLA administration. BLM in the blood was significantly lower after administration of BLM-PLA than BLM-SOL. The results indicate that BLM-PLA may become a useful tool in targeting chemotherapy for esophageal cancer.
在体内研究了博来霉素与可生物降解的聚-d，l-乳酸（BLM-PLA）结合用于食管癌靶向化疗的潜在效用。将给药后博来霉素的局部水平与注射博来霉素溶液（BLM-SOL）后的水平进行比较。在36只杂种犬中，通过右胸切开术将BLM-PLA或BLM-SOL注入上纵隔。给药后第10、20和30天，取出结缔组织、淋巴结、肺、肝、肾和脾，并测量博来霉素活性。与注射BLM-SOL相比，BLM-PLA给药后30天内在结缔组织和淋巴结中均检测到高活性的博来霉素。BLM-PLA给药后其他器官中的博来霉素活性较低。与BLM-SOL相比，BLM-PLA给药后血液中的博来霉素水平显著降低。结果表明，BLM-PLA可能成为食管癌靶向化疗的有用工具。
