通过三色免疫表型分析/荧光原位杂交技术直接检测慢性髓性白血病CD20阳性淋巴细胞中的费城染色体
Direct detection of the Philadelphia chromosome in CD20-positive lymphocytes in chronic myeloid leukemia by tri-color immunophenotyping/FISH.
作者信息
Torlakovic E, Litz C E, McClure J S, Brunning R D
机构信息
Department of Laboratory Medicine and Pathology, University of Minnesota Hospital and Clinics, Minneapolis.
出版信息
Leukemia. 1994 Nov;8(11):1940-3.
PMID:7526092
Abstract
Six patients with previously diagnosed chronic myelogenous leukemia (CML) were studied by a tri-color immunophenotyping/FISH method for direct determination of the Philadelphia (Ph) chromosome in B and T lymphocytes. Two patients had involvement of CD20-positive lymphocytes. CD3-positive lymphocytes in all patients were negative for the Ph chromosome.
摘要
采用三色免疫表型分析/荧光原位杂交（FISH）方法对6例先前已诊断为慢性粒细胞白血病（CML）的患者进行研究，以直接检测B淋巴细胞和T淋巴细胞中的费城（Ph）染色体。2例患者的CD20阳性淋巴细胞受累。所有患者的CD3阳性淋巴细胞的Ph染色体均为阴性。
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