Yamanaka R, Tanaka R, Saito T
Department of Neurosurgery, Niigata University.
Neurol Med Chir (Tokyo). 1994 Sep;34(9):583-7. doi: 10.2176/nmc.34.583.
The presence of tumor-infiltrating lymphocytes (TILs) and the expression of adhesion molecules were examined in 12 glioma tissues. Most TILs were T lymphocytes, and both cytotoxic/suppressor and helper/inducer. T lymphocyte phenotypes were found. Neural cell adhesion molecule was intensely expressed in 11 gliomas, and intercellular adhesion molecule-1 (ICAM-1) in seven. Many TILs were found only in gliomas expressing ICAM-1, but there was no relationship with clinical course in the patients.
在12例胶质瘤组织中检测肿瘤浸润淋巴细胞（TILs）的存在情况及黏附分子的表达。大多数TILs为T淋巴细胞，包括细胞毒性/抑制性T细胞和辅助/诱导性T细胞，发现了T淋巴细胞表型。神经细胞黏附分子在11例胶质瘤中强烈表达，细胞间黏附分子-1（ICAM-1）在7例中表达。仅在表达ICAM-1的胶质瘤中发现许多TILs，但与患者的临床病程无关。
