Ikeda K, Akiyama H, Haga C, Kondo H, Arima K, Oda T
Department of Neuropathology, Tokyo Institute of Psychiatry, Japan.
Neurosci Lett. 1994 Jun 20;174(2):157-9. doi: 10.1016/0304-3940(94)90010-8.
Massive argyrophilic thread-like structures (ATS) are observed in corticobasal degeneration and, in varied degrees, in some cases of progressive supranuclear palsy. Immunohistochemically, ATS has a full length of phosphorylated tau epitopes without ubiquitin. Gallyas- and immuno-electron microscopic observation revealed that ATS is a cytoskeletal abnormality occurred in both the inner and outer loop of the oligodendroglia. tau-Positive oligodendroglial tangles were distributed in the same region as ATS.
在皮质基底节变性中观察到大量嗜银丝状结构（ATS），在某些进行性核上性麻痹病例中也不同程度地观察到。免疫组织化学显示，ATS全长具有磷酸化tau表位，无泛素。加利亚斯染色和免疫电子显微镜观察显示，ATS是少突胶质细胞内环和外环均出现的细胞骨架异常。tau阳性的少突胶质细胞缠结分布在与ATS相同的区域。
