Vilafranca M, Wohlsein P, Trautwein G
Institute of Pathology, Hannover School of Veterinary Medicine, Germany.
Res Vet Sci. 1994 Jul;57(1):39-44. doi: 10.1016/0034-5288(94)90079-5.
Visceral glomerular epithelial cells (vGECs) originate from a mesenchymal blastema and transiently express cytokeratin during embryogenesis. There are no reports of cytokeratin expression in vGECs of mature, normal or damaged, human or other mammalian kidneys in vivo, but in vitro studies have provided evidence of the synthesis of cytokeratin in cultured vGECs. Cytokeratin expression was observed in vGECs in the damaged kidneys of four dogs with spontaneous renal diseases and, by using monoclonal antibodies, type 18 cytokeratin was identified. vGECs are apparently able to (re-) activate in vivo a mechanism for switching on the synthesis of cytokeratin in damaged glomeruli.
内脏肾小球上皮细胞（vGECs）起源于间充质胚基，在胚胎发育过程中短暂表达细胞角蛋白。目前尚无关于成熟、正常或受损的人类或其他哺乳动物肾脏的体内vGECs中细胞角蛋白表达的报道，但体外研究已提供了培养的vGECs中细胞角蛋白合成的证据。在四只患有自发性肾脏疾病的犬的受损肾脏的vGECs中观察到细胞角蛋白表达，并通过使用单克隆抗体鉴定出18型细胞角蛋白。vGECs显然能够在体内（重新）激活受损肾小球中开启细胞角蛋白合成的机制。
