Philip G H, Reddy P M, Ramamurthi R
Department of Zoology, Sri Krishnadevaraya University, Anantapur, India.
Acta Physiol Hung. 1994;82(1):61-7.
Protein metabolism was studied in the brain and muscle tissues of mice, Mus booduga after administering orally 50 mg/kg body weight of benzenehexachloride (BHC) daily for 1, 5 and 15 days. Both tissues exhibited considerable decline in all the protein fractions such as total, soluble and structural proteins. This corroborates with the increased levels of free amino acids (FAA) and protease. To fortify these alterations, elevation in the activities of aspartate aminotransferase (AAT), alanine aminotransferase (AlAT) and glutamate dehydrogenase (GDH) were noticed. The two nitrogenous end products namely, ammonia and urea levels were also increased. These results clearly demonstrate the impairment of protein metabolism due to sublethal BHC toxicity.
在每天口服50毫克/千克体重的六六六（BHC）1天、5天和15天后，对印度侏小鼠的大脑和肌肉组织中的蛋白质代谢进行了研究。两种组织中的所有蛋白质组分，如总蛋白、可溶性蛋白和结构蛋白，均出现显著下降。这与游离氨基酸（FAA）和蛋白酶水平的升高相一致。为了强化这些变化，观察到天冬氨酸转氨酶（AAT）、丙氨酸转氨酶（AlAT）和谷氨酸脱氢酶（GDH）的活性升高。两种含氮终产物，即氨和尿素水平也升高。这些结果清楚地表明，亚致死剂量的BHC毒性会损害蛋白质代谢。
