Weston A, Assem E S
Pharmacology Department, University College London, UK.
Agents Actions. 1994 Jun;41 Spec No:C138-9. doi: 10.1007/BF02007801.
Binding-inhibition studies involving human IgE antibody to suxamethonium, SUX (from a patient with a near-fatal reaction), were performed with five different quaternary ammonium compounds (QAC): three common ingredients of cosmetics and two commonly used disinfectants, cetrimide and benzalkonium. All the five QAC showed immunological cross-reaction with SUX. In addition, at high concentrations, they released histamine from basophils of normal subjects. Thus, QAC may be both sensitizers and histamine releasers.
对五例不同的季铵化合物（QAC）进行了结合抑制研究，这些化合物包括三种常见的化妆品成分以及两种常用消毒剂西曲溴铵和苯扎氯铵，研究涉及一名曾发生近乎致命反应患者的人免疫球蛋白E（IgE）抗体与琥珀胆碱（SUX）的结合。所有这五种QAC均显示与SUX存在免疫交叉反应。此外，在高浓度时，它们会从正常受试者的嗜碱性粒细胞中释放组胺。因此，QAC可能既是致敏原又是组胺释放剂。
