Sonea I M, Bowker R M, Robinson N E, Broadstone R V
Department of Anatomy, Michigan State University, East Lansing 48824-1314.
Am J Vet Res. 1994 Aug;55(8):1066-74.
Distribution of pulmonary nerves immunoreactive for either substance P or calcitonin gene-related peptide was determined, using immunohistochemical methods on healthy lungs from adult equids. The overall patterns of distribution of substance P and calcitonin gene-related peptide-like immunoreactivity were similar. Distribution of immunoreactive nerves was not uniform throughout the lungs; nerve fibers immunoreactive for these peptides were more frequently observed near the hilus of the lung than in the caudal lobes or in the periphery of the lung. Nerve fibers immunoreactive for substance P or calcitonin gene-related peptide were most abundant in the lamina propria of the trachea and larger airways, particularly within and directly below the airway epithelium; they were also frequently associated with bronchial and pulmonary vessels. Presence of nerve fibers immunoreactive for substance P and calcitonin gene-related peptide in peribronchial neural ganglia indicated that these sensory nerves may modulate parasympathetic regulation of pulmonary function. Nerve fibers immunoreactive for substance P and calcitonin gene-related peptide were, therefore, well placed to detect inhaled agents and to contribute to the pulmonary response to irritants and pathogens.
利用免疫组织化学方法，对成年马科动物的健康肺组织进行研究，以确定对P物质或降钙素基因相关肽呈免疫反应的肺神经分布情况。P物质和降钙素基因相关肽样免疫反应的总体分布模式相似。免疫反应性神经在整个肺内分布并不均匀；与尾叶或肺周边相比，这些肽的免疫反应性神经纤维在肺门附近更常见。对P物质或降钙素基因相关肽呈免疫反应的神经纤维在气管和较大气道的固有层中最为丰富，尤其是在气道上皮内和正下方；它们也经常与支气管和肺血管相关。支气管周围神经节中存在对P物质和降钙素基因相关肽呈免疫反应的神经纤维，表明这些感觉神经可能调节肺功能的副交感神经调节。因此，对P物质和降钙素基因相关肽呈免疫反应的神经纤维处于良好位置，可检测吸入剂，并有助于肺部对刺激物和病原体的反应。
