Stone R A, McGlinn A M
Department of Ophthalmology, University of Pennsylvania School of Medicine, Scheie Eye Institute, Philadelphia 19104-6075.
Invest Ophthalmol Vis Sci. 1988 Feb;29(2):305-10.
Using immunohistochemical methods, calcitonin gene-related peptide localizes to peripheral nerve fibers of the human and rhesus monkey eye. Immunoreactive nerve fibers are found in the cornea, about limbal blood vessels and in the trabecular meshwork. Many immunoreactive iris nerve fibers are present, mostly within the stroma. A particularly dense network occurs just anterior to the iris sphincter muscle, but only a small number of immunoreactive nerve fibers are visualized within it. The ciliary muscle and ciliary processes also are innervated. Immunoreactive nerve fibers are associated with uveal blood vessels, most prominently in the choroid and ciliary body. Apposition of immunoreactive nerve fibers to uveal melanocytes is seen. In lower mammalian species, calcitonin gene-related peptide co-localizes with substance P in many ocular nerve fibers. The comparative distribution in human and monkey eyes of nerve fibers immunoreactive to these two peptides is discussed.
运用免疫组化方法，降钙素基因相关肽定位于人和恒河猴眼睛的外周神经纤维。在角膜、角膜缘血管周围及小梁网中发现有免疫反应性神经纤维。虹膜中有许多免疫反应性神经纤维，大多位于基质内。在虹膜括约肌前方有一个特别密集的网络，但其中仅可见少量免疫反应性神经纤维。睫状肌和睫状突也有神经支配。免疫反应性神经纤维与葡萄膜血管相关，在脉络膜和睫状体中最为明显。可见免疫反应性神经纤维与葡萄膜黑素细胞相邻。在低等哺乳动物中，降钙素基因相关肽在许多眼神经纤维中与P物质共定位。本文讨论了这两种肽免疫反应性神经纤维在人眼和猴眼中的比较分布。
