一类新型四环素（甘氨酰环素）对在耐四环素、由TetM蛋白保护的核糖体上发生的蛋白质合成的抑制作用。
Inhibition of protein synthesis occurring on tetracycline-resistant, TetM-protected ribosomes by a novel class of tetracyclines, the glycylcyclines.
作者信息
Rasmussen B A, Gluzman Y, Tally F P
机构信息
Department of Molecular Biology, American Cyanamid Company, Pearl River, New York 10965.
出版信息
Antimicrob Agents Chemother. 1994 Jul;38(7):1658-60. doi: 10.1128/AAC.38.7.1658.
Abstract
One of the two major mechanisms of tetracycline resistance is ribosomal protection. Of this resistance type, tet(M) is the best characterized. Although the mechanism of tet(M) resistance has not yet been fully elucidated, it has been demonstrated that ribosomes isolated from a tet(M) strain are resistant to inhibition of protein synthesis by tetracycline. A new generation of tetracycline compounds, the glycylcyclines, that are able to inhibit protein synthesis occurring on tetracycline-resistant, TetM-protected ribosomes, as well as wild-type, tetracycline-sensitive ribosomes, have been identified.
摘要
四环素耐药性的两种主要机制之一是核糖体保护。在这种耐药类型中，tet(M)的特征最为明确。尽管tet(M)耐药性的机制尚未完全阐明，但已证明从tet(M)菌株分离出的核糖体对四环素抑制蛋白质合成具有抗性。新一代四环素化合物——甘氨酰环素已被鉴定出来，它能够抑制在四环素耐药、TetM保护的核糖体以及野生型、四环素敏感核糖体上发生的蛋白质合成。
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本文引用的文献
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In vitro and in vivo antibacterial activities of the glycylcyclines, a new class of semisynthetic tetracyclines.新型半合成四环素类——甘氨酰环素的体外和体内抗菌活性
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Nucleotide sequence of the tetM tetracycline resistance determinant of the streptococcal conjugative shuttle transposon Tn1545.链球菌接合型穿梭转座子Tn1545的四环素抗性决定子tetM的核苷酸序列。
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