链球菌对四环素的耐药性在蛋白质合成水平介导。
Streptococcal tetracycline resistance mediated at the level of protein synthesis.
作者信息
Burdett V
出版信息
J Bacteriol. 1986 Feb;165(2):564-9. doi: 10.1128/jb.165.2.564-569.1986.
Abstract
The mechanism of tetracycline resistance was examined in strains containing each of the three previously identified resistance determinants in Streptococcus spp. Uptake of tetracycline was measured in tetracycline-sensitive cells as well as in cells containing each of the three resistance determinants. In cells containing tetL, uptake was not observed. However, in sensitive cells and cells containing either tetM or tetN, tetracycline was accumulated approximately 25-fold against a concentration gradient. Furthermore, there was no evidence for modification of intracellular tetracycline recovered from sensitive, tetM, or tetN cells. Protein synthesis in extracts derived from organisms containing tetM or tetN was resistant to tetracycline. In contrast, extracts of sensitive and tetL cells were sensitive to tetracycline.
摘要
在含有链球菌属中先前鉴定的三种抗性决定因素的菌株中，研究了四环素抗性机制。在四环素敏感细胞以及含有这三种抗性决定因素的细胞中测量了四环素的摄取情况。在含有tetL的细胞中，未观察到摄取。然而，在敏感细胞以及含有tetM或tetN的细胞中，四环素逆浓度梯度积累了约25倍。此外，没有证据表明从敏感、tetM或tetN细胞中回收的细胞内四环素发生了修饰。含有tetM或tetN的生物体提取物中的蛋白质合成对四环素具有抗性。相比之下，敏感和tetL细胞的提取物对四环素敏感。
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