Soini H, Riekkola M L, Novotny M V
Department of Chemistry, Indiana University, Bloomington, 47405.
J Chromatogr A. 1994 Oct 7;680(2):623-34. doi: 10.1016/0021-9673(94)85162-x.
Two-component polymer mixtures of polyethylene oxide-polydextran have been investigated as unique separation media for capillary electrophoresis. The effects of concentration of the individual polymers and their mixtures on the electroosmotic velocity and electrophoretic mobility of small pharmaceutical compounds were investigated. The molecular masses of polymers, buffer concentrations and percentages of organic solvents and cyclodextrins were varied to explore their effects on the separation process. The plate height against field strength curves were also generated for a better understanding of the kinetic processes involved. The two-component polymer mixtures were found as stable and selective media for the analysis of an anti-ulcer drug famotidine directly in untreated urine.
聚环氧乙烷-聚右旋糖酐的双组分聚合物混合物已被研究作为毛细管电泳独特的分离介质。研究了各聚合物及其混合物的浓度对小药物化合物电渗速度和电泳迁移率的影响。改变聚合物的分子量、缓冲液浓度、有机溶剂和环糊精的百分比，以探索它们对分离过程的影响。还生成了塔板高度与场强曲线，以便更好地理解所涉及的动力学过程。发现双组分聚合物混合物是直接分析未经处理尿液中抗溃疡药物法莫替丁的稳定且选择性的介质。
