扩展B7（CD80）基因家族。
Extending the B7 (CD80) gene family.
作者信息
Linsley P S, Peach R, Gladstone P, Bajorath J
机构信息
Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121.
出版信息
Protein Sci. 1994 Aug;3(8):1341-3. doi: 10.1002/pro.5560030820.
Abstract
B7-1 and B7-2 are members of the immunoglobulin superfamily (IgSF) and important regulators of T cell-mediated immune responses. Despite sharing only limited sequence identity, B7-1 and B7-2 bind common receptors, CD28 and CTLA-4, on T cells and have similar functional properties. We have found that the extracellular V (ariable)-like domains of B7-1 and B7-2 share significant sequence similarities with 3 major histocompatibility complex (MHC)-encoded members of the IgSF: butyrophilin, myelin/oligodendrocyte glycoprotein, and the chicken MHC molecule, B-G. This raises the question whether there is an evolutionary link between the MHC, which encodes molecules regulating the antigen specificity of T lymphocyte responses, and B7 molecules, which co-stimulate these responses in antigen-nonspecific fashion.
摘要
B7-1和B7-2是免疫球蛋白超家族（IgSF）的成员，也是T细胞介导的免疫反应的重要调节因子。尽管B7-1和B7-2仅具有有限的序列同一性，但它们能结合T细胞上的共同受体CD28和CTLA-4，并具有相似的功能特性。我们发现，B7-1和B7-2的细胞外类可变（V）结构域与免疫球蛋白超家族的3个主要组织相容性复合体（MHC）编码成员具有显著的序列相似性：嗜乳脂蛋白、髓磷脂/少突胶质细胞糖蛋白以及鸡的MHC分子B-G。这就提出了一个问题，即编码调节T淋巴细胞反应抗原特异性分子的MHC与以抗原非特异性方式共刺激这些反应的B7分子之间是否存在进化联系。
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本文引用的文献
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Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex.髓鞘/少突胶质细胞糖蛋白是主要组织相容性复合体中编码的免疫球蛋白超家族一个亚组的成员。
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Connections between the immune system and the nervous system.免疫系统与神经系统之间的联系。
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Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation.B7-2的克隆：一种共刺激人类T细胞增殖的CTLA-4反受体。
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B70 antigen is a second ligand for CTLA-4 and CD28.B70抗原是CTLA-4和CD28的第二种配体。
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Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production.小鼠B7-2，一种可共刺激T细胞增殖和白细胞介素2产生的CTLA4替代型反受体。
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