Kolb J P, Paul-Eugène N, Ouaaz F, Yamaoka K, Mossalayi D, Dugas B
Unité INSERM U365, Institut Curie, Paris.
C R Seances Soc Biol Fil. 1994;188(1):59-66.
Ligation of the low affinity IgE receptor by specific monoclonal antibodies or multivalent IgE complexes result in the transduction of signals which differ according to the CD23 isotype expressed by the various cell types. In B lymphocytes, it elicits the early activation of phospholipase C through a mechanism involving a G-protein insensitive to Pertussis toxin, followed by a late phase of cAMP accumulation. In monocytes, which express the CD23b isoform, ligation of CD23 was also found to induce a delayed accumulation of cAMP, that was largely dependent on a prior cGMP increase through a mechanism involving the activation of a NO synthase. This pathway, which appears to be exacerbated in allergic diseases, seems to play an important role in the differentiation of cells of the monocytic lineage, their capacity to release proinflammatory mediators and their cytotoxic functions.
用特异性单克隆抗体或多价IgE复合物连接低亲和力IgE受体，会导致信号转导，这些信号因不同细胞类型表达的CD23同种型而异。在B淋巴细胞中，它通过一种涉及对百日咳毒素不敏感的G蛋白的机制引发磷脂酶C的早期激活，随后是cAMP积累的晚期阶段。在表达CD23b同种型的单核细胞中，也发现CD23的连接会诱导cAMP的延迟积累，这在很大程度上依赖于通过涉及一氧化氮合酶激活的机制使cGMP先增加。这条途径在过敏性疾病中似乎会加剧，似乎在单核细胞系细胞的分化、它们释放促炎介质的能力及其细胞毒性功能中发挥重要作用。
