Degtiarenko V I, Fedchuk A S
Mol Biol (Mosk). 1977 May-Jun;11(3):516-20.
A mechanism responsible for proteolytic deproteinization of influenza virus A2 Hong-Kong (I)68 by plasmatic membranes of sensitive cells was studied. Presence of trypsinlike protease in plasmatic membranes of white mice lungs was demonstrated. A considerable inhibition of the membrane proteolitic activity was obtained in the presence of epsilon-aminocaproic acid. Disintegration of the virus labeled by [3H]uridine by plasmatic membranes was investigated and it was found that this process required ATP. Inhibition of the protease activity by epsilon-aminocaproic acid led to the suppression of deproteinization of influenza virus. The experimental data obtained indicate that the proteolytic enzymes of plasmatic membranes participate in the complex process of virus "uncoating".
研究了敏感细胞的质膜对甲型流感病毒A2香港（I）68进行蛋白水解脱蛋白作用的机制。证明了小白鼠肺质膜中存在类胰蛋白酶。在ε-氨基己酸存在的情况下，膜蛋白水解活性受到显著抑制。研究了质膜对用[3H]尿苷标记的病毒的分解作用，发现该过程需要ATP。ε-氨基己酸对蛋白酶活性的抑制导致流感病毒脱蛋白作用的抑制。所获得的实验数据表明，质膜中的蛋白水解酶参与了病毒“脱壳”的复杂过程。
