Divocha V A, Grigor'eva I G, Bukrinskaia A G
Vopr Virusol. 1990 Sep-Oct;35(5):370-2.
In uninfected animals, the level of protease and protease-inhibiting activities in the serum are in balance which is broken after influenza A virus infection. Most profound changes occur within the first few hours after infection. In 6 hours postinfection the amount of protease decreases both in the lungs and serum of the infected animals, and the protease-inhibiting activity increases. In the period of the highest accumulation of the infectious virus 2 days after infection, proteolytic activity also decreases, this decrease coinciding with that of the inhibiting activity. The third period of increased protease activity also coincides with amplification of infectious virus progeny and appears to be associated with consequences of virus infection and bacterial superinfection.
在未感染的动物中，血清中蛋白酶水平与蛋白酶抑制活性处于平衡状态，甲型流感病毒感染后这种平衡被打破。感染后的最初几个小时内变化最为显著。感染后6小时，感染动物的肺部和血清中蛋白酶量均减少，而蛋白酶抑制活性增加。感染后2天，在传染性病毒积累量最高的时期，蛋白水解活性也降低，这种降低与抑制活性的降低相一致。蛋白酶活性增加的第三个时期也与传染性病毒子代的扩增同时出现，并且似乎与病毒感染和细菌重叠感染的后果有关。
