Liu Y, Chen H, Dong J M, Chiu J F
Department of Biochemistry, College of Medicine, University of Vermont, Burlington 05405.
Biochem Biophys Res Commun. 1994 Nov 30;205(1):700-5. doi: 10.1006/bbrc.1994.2722.
A distal RA responsive cis-acting element has been identified in the 5'-flanking region of the alpha-fetoprotein gene by transfection of different deletion mutants of AFP-CAT fusion gene. The retinoic acid receptor specifically binds to this RA responsive cis-acting element in mobility shift assays. Furthermore, this cis-acting element functions in exogenous TK promoter in transient cotransfection assays. This study suggests a role for the RA responsive cis-acting element in the RA induction of alpha-fetoprotein gene expression.
