Fas配体介导人T淋巴细胞中激活诱导的细胞死亡。
Fas ligand mediates activation-induced cell death in human T lymphocytes.
作者信息
Alderson M R, Tough T W, Davis-Smith T, Braddy S, Falk B, Schooley K A, Goodwin R G, Smith C A, Ramsdell F, Lynch D H
机构信息
Immunex Research and Developmental Corporation, Seattle, Washington 98101.
出版信息
J Exp Med. 1995 Jan 1;181(1):71-7. doi: 10.1084/jem.181.1.71.
Abstract
A significant proportion of previously activated human T cells undergo apoptosis when triggered through the CD3/T cell receptor complex, a process termed activation-induced cell death (AICD). Ligation of Fas on activated T cells by either Fas antibodies or recombinant human Fas-ligand (Fas-L) also results in cytolysis. We demonstrate that these two pathways of apoptosis are causally related. Stimulation of previously activated T cells resulted in the expression of Fas-L mRNA and lysis of Fas-positive target cells. Fas-L antagonists inhibited AICD of T cell clones and staphylococcus enterotoxin B (SEB)-specific T cell lines. The data indicate AICD in previously stimulated T cells is mediated by Fas/Fas-L interactions.
摘要
相当一部分先前被激活的人类T细胞在通过CD3/T细胞受体复合物触发时会发生凋亡，这一过程称为激活诱导的细胞死亡（AICD）。用Fas抗体或重组人Fas配体（Fas-L）连接活化T细胞上的Fas也会导致细胞溶解。我们证明这两种凋亡途径存在因果关系。刺激先前活化的T细胞会导致Fas-L mRNA的表达以及Fas阳性靶细胞的裂解。Fas-L拮抗剂可抑制T细胞克隆和葡萄球菌肠毒素B（SEB）特异性T细胞系的AICD。数据表明，先前受刺激的T细胞中的AICD是由Fas/Fas-L相互作用介导的。
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本文引用的文献
1
2
Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide.自身免疫性lpr/lpr小鼠的成熟T细胞在抗原刺激下的自杀过程中存在缺陷。
Proc Natl Acad Sci U S A. 1993 May 15;90(10):4409-13. doi: 10.1073/pnas.90.10.4409.
3
Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells.在活化而非静息的外周血T细胞中诱导激活驱动的死亡（凋亡）。
J Immunol. 1993 May 15;150(10):4338-45.
4
CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF.CD30抗原是霍奇金淋巴瘤的一种标志物，它是一种受体，其配体定义了一个与肿瘤坏死因子具有同源性的新兴细胞因子家族。
Cell. 1993 Jul 2;73(7):1349-60. doi: 10.1016/0092-8674(93)90361-s.
5
Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor.CD27配体的分子与生物学特性鉴定出一个与肿瘤坏死因子具有同源性的新细胞因子家族。
Cell. 1993 May 7;73(3):447-56. doi: 10.1016/0092-8674(93)90133-b.
6
Autoimmune gld mutation uncouples suicide and cytokine/proliferation pathways in activated, mature T cells.自身免疫性gld突变使活化的成熟T细胞中的自杀途径与细胞因子/增殖途径解偶联。
Eur J Immunol. 1993 Sep;23(9):2379-82. doi: 10.1002/eji.1830230951.
7
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Immunol Today. 1993 Jul;14(7):338-9. doi: 10.1016/0167-5699(93)90231-9.
8
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Eur J Immunol. 1993 Jul;23(7):1513-22. doi: 10.1002/eji.1830230718.
9
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10
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