Mochizuki M, Yokoyama T, Sakai T
Department of Pathology, Jichi Medical School, Tochigi, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1994 Aug;32(8):752-6.
The expression of tenascin, a of extracellular matrix glycoprotein, was studied immunohistochemically in the lungs of 22 autopsy cases, including chronic idiopathic interstitial pneumonia (chronic IIP) associated with lung cancer (5 cases), chronic IIP without lung cancer (6 cases), acute idiopathic interstitial pneumonia (acute IIP; 6 cases) and alveolar pneumonia (AP; 5 cases). In the honeycomb lesion of chronic IIP, tenascin expression was observed in the basement membrane of metaplastic epithelia and in the subepithelial stroma of thickened septa with fibrosis. In the non-honeycomb area of chronic IIP, tenascin was expressed in mildly thickened alveolar walls with fibrosis. The distribution of tenascin expression in chronic IIP associated with lung cancer resembled that in chronic IIP without lung cancer. In acute IIP, tenascin expression was observed in mildly thickened alveolar walls with fibrosis, in organizing hyaline membranes. In AP, tenascin was expressed in organizing exudate of alveoli and was scarcely observed in the alveolar wall. It is very possible that tenascin is associated with the fibrosing process and remodelling in IIP, and has a promoting effect in carcinogenesis in IIP lung.
采用免疫组织化学方法，对22例尸检肺组织中细胞外基质糖蛋白腱生蛋白的表达进行了研究，这些病例包括合并肺癌的慢性特发性间质性肺炎（慢性IIP，5例）、无肺癌的慢性IIP（6例）、急性特发性间质性肺炎（急性IIP，6例）和肺泡性肺炎（AP，5例）。在慢性IIP的蜂窝状病变中，在化生上皮的基底膜以及伴有纤维化的增厚间隔的上皮下基质中观察到腱生蛋白表达。在慢性IIP的非蜂窝状区域，腱生蛋白在伴有纤维化的轻度增厚的肺泡壁中表达。合并肺癌的慢性IIP中腱生蛋白表达的分布与无肺癌的慢性IIP相似。在急性IIP中，在伴有纤维化的轻度增厚的肺泡壁以及机化透明膜中观察到腱生蛋白表达。在AP中，腱生蛋白在肺泡的机化渗出物中表达，而在肺泡壁中几乎未观察到。腱生蛋白很可能与IIP中的纤维化过程和重塑有关，并对IIP肺中的致癌作用有促进作用。
