Zhou C, Nagayama N, Ohtsuka Y, Sato K, Kurashima A, Hebisawa A
Department of Internal Medicine, Tokyo National Chest Hospital, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1995 Aug;33(8):829-34.
To study pathologic changes in small airways in acute interstitial pneumonia (AI), changes in the terminal or respiratory bronchioles in one patient with AI and in three patients with acute exacerbations of chronic interstitial pneumonia (grouped together as the AI group) were compared to those in five patients with chronic idiopathic interstitial pneumonia (IIP) without acute exacerbation. Specimens obtained during autopsy were examined by light microscopy. In the AI group, mononuclear cells had infiltrated the lumen in 47 (23.7%) of the 198 bronchioles examined, and granulation tissue was found in 101 (51.0%). In the IIP group, no changes were found in 37 (97.4%) of the 38 bronchioles examined. Therefore, mononuclear cell infiltration and granulation tissue are common in the bronchioles of patients with acute interstitial pneumonia, but not in those of patients with chronic interstitial pneumonia without acute exacerbation.
为研究急性间质性肺炎（AI）中小气道的病理变化，将1例AI患者和3例慢性间质性肺炎急性加重患者（合并为AI组）的终末细支气管或呼吸性细支气管的变化与5例无急性加重的慢性特发性间质性肺炎（IIP）患者的进行比较。尸检获取的标本经光学显微镜检查。在AI组，198个细支气管中有47个（23.7%）管腔内有单核细胞浸润，101个（51.0%）发现有肉芽组织。在IIP组，38个细支气管中有37个（97.4%）未发现变化。因此，单核细胞浸润和肉芽组织在急性间质性肺炎患者的细支气管中常见，但在无急性加重的慢性间质性肺炎患者的细支气管中不常见。
