Shirai T
Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan.
Tohoku J Exp Med. 1994 May;173(1):133-40. doi: 10.1620/tjem.173.133.
Autoimmune disease is a polygenic disease in which various genetic factors play crucial roles. The familial clustering and the association of HLA haplotypes have been well-recognized. There is a close association between chronic lymphocytic leukemia (CLL) and autoimmune disease. Like autoimmune diseases, CLL is the type of leukemia most often occurring among close relatives. The patients with CLL frequently share common HLA haplotypes with relatives with autoimmune disease. As the majority of CLL is of CD5+ B-cell type, and as CD5+ B cells are suggested to be involved in autoimmunity, certain regulatory abnormalities in the proliferation and differentiation of CD5 B cells may be involved in both B-CLL and autoimmune disease. I discuss here the possibility that different, but related, MHC haplotypes would predispose either to autoimmune disease or to B-CLL, based on our findings obtained from MHC (H-2)-congenic New Zealand mouse strains.
自身免疫性疾病是一种多基因疾病，其中各种遗传因素起着关键作用。家族聚集性以及HLA单倍型的关联性已得到充分认识。慢性淋巴细胞白血病（CLL）与自身免疫性疾病之间存在密切关联。与自身免疫性疾病一样，CLL是近亲中最常发生的白血病类型。CLL患者经常与患有自身免疫性疾病的亲属共享常见的HLA单倍型。由于大多数CLL是CD5 + B细胞类型，并且由于提示CD5 + B细胞参与自身免疫，CD5 B细胞增殖和分化中的某些调节异常可能与B - CLL和自身免疫性疾病都有关。基于我们从MHC（H - 2）同源的新西兰小鼠品系获得的研究结果，我在此讨论不同但相关的MHC单倍型易患自身免疫性疾病或B - CLL的可能性。
