Chrispeels M J, Agre P
Department of Biology, University of California San Diego, La Jolla 92093-0116.
Trends Biochem Sci. 1994 Oct;19(10):421-5. doi: 10.1016/0968-0004(94)90091-4.
Certain biological membranes, such as the erythrocyte plasma membrane, have a high osmotic water permeability, and such membranes have long been suspected of harboring water channels. The molecular identity of these channels has now been established with the purification of water-channel proteins and the cloning of the genes encoding them. Homologous water-channel proteins, called 'aquaporins', are present in plants and animals. These channels are water selective and do not allow ions or metabolites to pass through them. Their discovery is providing new insights into how plant and animal cells facilitate and regulate the passage of water through their membranes.
某些生物膜,如红细胞质膜,具有高渗透水通透性,长期以来人们一直怀疑这类膜中存在水通道。现在,随着水通道蛋白的纯化以及编码它们的基因的克隆,这些通道的分子身份已经确定。在植物和动物中都存在同源的水通道蛋白,称为“水孔蛋白”。这些通道具有水选择性,不允许离子或代谢物通过。它们的发现为植物和动物细胞如何促进和调节水通过其膜的过程提供了新的见解。