缺血后小鼠脑内Fas抗原mRNA的诱导
Fas antigen mRNA induction in postischemic murine brain.
作者信息
Matsuyama T, Hata R, Tagaya M, Yamamoto Y, Nakajima T, Furuyama J, Wanaka A, Sugita M
机构信息
Fifth Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
出版信息
Brain Res. 1994 Sep 19;657(1-2):342-6. doi: 10.1016/0006-8993(94)90989-x.
Fas antigen mRNA induction in the brain was examined using a transient global cerebral ischemia model in BALB/C mice. Northern blot analysis revealed little Fas antigen mRNA expression in the brains of sham-operated mice. A marked induction of Fas mRNA expression was detected in the brains of mice 6 h after 30 min of cerebral ischemia. These results suggest a possible apoptotic mechanism for cell death, mediated by the Fas antigen, in postischemic brain.
使用BALB/C小鼠的短暂性全脑缺血模型，检测大脑中Fas抗原mRNA的诱导情况。Northern印迹分析显示，假手术小鼠大脑中几乎没有Fas抗原mRNA表达。在大脑缺血30分钟后6小时的小鼠大脑中，检测到Fas mRNA表达显著诱导。这些结果提示，在缺血后大脑中，由Fas抗原介导的细胞死亡可能存在凋亡机制。
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