Rossini P M, Narici L, Martino G, Pasquarelli A, Peresson M, Pizzella V, Tecchio F, Romani G L
Divisione di Neurologia, Ospedale Fatebenefratelli, Rome, Italy.
Electroencephalogr Clin Neurophysiol. 1994 Dec;91(6):476-82. doi: 10.1016/0013-4694(94)90168-6.
This paper represents the first neuromagnetic systematic investigation of the asymmetries between the sources activated in the right and left hemispheres after electric median nerve stimulation. We focused our attention on the location and strength of the equivalent sources activated in the primary somatosensory cortex contralateral to the stimulated nerve in the 50 msec post-stimulus epoch. The spatial coordinates of the equivalent sources did not differ statistically significantly in the two hemispheres. Minor individual asymmetries are shown to be related to the interhemispheric differences in the position of the central sulcus as revealed by MRI investigation. The equivalent sources were significantly stronger in the left hemisphere. When comparing the location of the generators across individuals, we show that interhemispheric differences fluctuate less than absolute values. A quantitative evaluation of these findings is also given. Based on these results, a normative data set has been established, to be used as a baseline in following up changes of interhemispheric asymmetries due to hemispheric lesions and subsequent cortical reorganization.
本文首次对电刺激正中神经后左右半球激活源之间的不对称性进行了神经磁学系统研究。我们将注意力集中在刺激后50毫秒内，受刺激神经对侧的初级体感皮层中激活的等效源的位置和强度上。等效源的空间坐标在两个半球中没有统计学上的显著差异。MRI研究显示，个体间的微小不对称与中央沟位置的半球间差异有关。等效源在左半球明显更强。当比较个体间发生器的位置时，我们发现半球间差异的波动小于绝对值。还对这些发现进行了定量评估。基于这些结果，建立了一个标准数据集，用作后续追踪半球病变及随后皮层重组导致的半球间不对称性变化的基线。
